FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070791978> ?p ?o ?g. }

• W2070791978 endingPage "250" @default.
• W2070791978 startingPage "239" @default.
• W2070791978 abstract "Two strains of pathogenic Naegleria were employed to infect mice and monkey kidney (Vero line) cell cultures. Mice were infected intranasally. Moribund mice were sacrificed and their brains processed for light and electron microscopy. The normal architecture of the infected brain was completely destroyed; the olfactory lobes and the cerebral cortex showed the heaviest damage. The inflammatory response was mainly in the form of neutrophil polymorphs (PMN) and was confined to the olfactory lobes and the superficial regions of cerebral cortex. Numerous amebas were seen interspersed with the degenerating neurons, glial processes, and PMN. Most conspicuous were the food vacuoles which contained host tissue in various stages of digestion. Amebas in the brain tissue also produced many micropinocytotic vesicles from the surface of the plasma membrane. These vesicles are interpreted as vehicles of transport of nutritive materials from the host tissue. The infected cell culture showed the characteristic cytopathic effect (CPE). The CPE was chiefly in the form of cell shrinkage, nuclear pycnosis and discontinuity of cell sheet. Amebas were often seen in an intracellular location. The Vero cells produced many fuzzy pinocytotic vesicles at these loci where the ameba plasma membrane and Vero cell membrane were in close apposition; the probable significance of this is discussed. Most impressive, however, were the pseudopodial formation and capturing of the host material which indicated the great phagocytic activity of the amebas. This was confirmed further by the presence of large numbers of food vacuoles containing host material in various stages of digestion. These observations show that the amebas invade and destroy the brain tissue by active phagocytosis." @default.
• W2070791978 created "2016-06-24" @default.
• W2070791978 creator A5018972640 @default.
• W2070791978 creator A5065410386 @default.
• W2070791978 date "1974-05-01" @default.
• W2070791978 modified "2023-10-16" @default.
• W2070791978 title "Light and Electron Microsopic Observations on the Pathogenesis of<i>Naegleria fowleri</i>in Mouse Brain and Tissue Culture" @default.
• W2070791978 cites W124053801 @default.
• W2070791978 cites W1632464623 @default.
• W2070791978 cites W1879900969 @default.
• W2070791978 cites W1958178116 @default.
• W2070791978 cites W1972207985 @default.
• W2070791978 cites W1986195590 @default.
• W2070791978 cites W1989773103 @default.
• W2070791978 cites W1998803800 @default.
• W2070791978 cites W1998804252 @default.
• W2070791978 cites W2019126938 @default.
• W2070791978 cites W2036270058 @default.
• W2070791978 cites W2053625002 @default.
• W2070791978 cites W2056827941 @default.
• W2070791978 cites W2067590951 @default.
• W2070791978 cites W2073182942 @default.
• W2070791978 cites W2092132764 @default.
• W2070791978 cites W2123018141 @default.
• W2070791978 cites W2137203430 @default.
• W2070791978 cites W2151738192 @default.
• W2070791978 cites W2214483804 @default.
• W2070791978 cites W2308795916 @default.
• W2070791978 cites W2318770687 @default.
• W2070791978 cites W2328082002 @default.
• W2070791978 cites W2334838056 @default.
• W2070791978 cites W3148588680 @default.
• W2070791978 cites W3213563054 @default.
• W2070791978 doi "https://doi.org/10.1111/j.1550-7408.1974.tb03648.x" @default.
• W2070791978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4838474" @default.
• W2070791978 hasPublicationYear "1974" @default.
• W2070791978 type Work @default.
• W2070791978 sameAs 2070791978 @default.
• W2070791978 citedByCount "55" @default.
• W2070791978 countsByYear W20707919782012 @default.
• W2070791978 countsByYear W20707919782014 @default.
• W2070791978 countsByYear W20707919782016 @default.
• W2070791978 countsByYear W20707919782017 @default.
• W2070791978 countsByYear W20707919782019 @default.
• W2070791978 countsByYear W20707919782021 @default.
• W2070791978 crossrefType "journal-article" @default.
• W2070791978 hasAuthorship W2070791978A5018972640 @default.
• W2070791978 hasAuthorship W2070791978A5065410386 @default.
• W2070791978 hasConcept C102568950 @default.
• W2070791978 hasConcept C120665830 @default.
• W2070791978 hasConcept C121332964 @default.
• W2070791978 hasConcept C130316041 @default.
• W2070791978 hasConcept C147075424 @default.
• W2070791978 hasConcept C1491633281 @default.
• W2070791978 hasConcept C159047783 @default.
• W2070791978 hasConcept C190062978 @default.
• W2070791978 hasConcept C2522874641 @default.
• W2070791978 hasConcept C2775996393 @default.
• W2070791978 hasConcept C2776193487 @default.
• W2070791978 hasConcept C2778621254 @default.
• W2070791978 hasConcept C2781155112 @default.
• W2070791978 hasConcept C28005876 @default.
• W2070791978 hasConcept C40017333 @default.
• W2070791978 hasConcept C41625074 @default.
• W2070791978 hasConcept C54355233 @default.
• W2070791978 hasConcept C55493867 @default.
• W2070791978 hasConcept C81885089 @default.
• W2070791978 hasConcept C86803240 @default.
• W2070791978 hasConcept C89138240 @default.
• W2070791978 hasConcept C89423630 @default.
• W2070791978 hasConcept C93877712 @default.
• W2070791978 hasConcept C95444343 @default.
• W2070791978 hasConceptScore W2070791978C102568950 @default.
• W2070791978 hasConceptScore W2070791978C120665830 @default.
• W2070791978 hasConceptScore W2070791978C121332964 @default.
• W2070791978 hasConceptScore W2070791978C130316041 @default.
• W2070791978 hasConceptScore W2070791978C147075424 @default.
• W2070791978 hasConceptScore W2070791978C1491633281 @default.
• W2070791978 hasConceptScore W2070791978C159047783 @default.
• W2070791978 hasConceptScore W2070791978C190062978 @default.
• W2070791978 hasConceptScore W2070791978C2522874641 @default.
• W2070791978 hasConceptScore W2070791978C2775996393 @default.
• W2070791978 hasConceptScore W2070791978C2776193487 @default.
• W2070791978 hasConceptScore W2070791978C2778621254 @default.
• W2070791978 hasConceptScore W2070791978C2781155112 @default.
• W2070791978 hasConceptScore W2070791978C28005876 @default.
• W2070791978 hasConceptScore W2070791978C40017333 @default.
• W2070791978 hasConceptScore W2070791978C41625074 @default.
• W2070791978 hasConceptScore W2070791978C54355233 @default.
• W2070791978 hasConceptScore W2070791978C55493867 @default.
• W2070791978 hasConceptScore W2070791978C81885089 @default.
• W2070791978 hasConceptScore W2070791978C86803240 @default.
• W2070791978 hasConceptScore W2070791978C89138240 @default.
• W2070791978 hasConceptScore W2070791978C89423630 @default.
• W2070791978 hasConceptScore W2070791978C93877712 @default.
• W2070791978 hasConceptScore W2070791978C95444343 @default.
• W2070791978 hasIssue "2" @default.
• W2070791978 hasLocation W20707919781 @default.

• next