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- W2070794927 endingPage "89" @default.
- W2070794927 startingPage "75" @default.
- W2070794927 abstract "Tissue factor (TF) is the key initiator of the coagulation cascade. The exposure of subendothelial TF after vessel injury to blood is a critical step in hemostasis and in the pathogenesis of arterial and venous thrombotic disorders. Moreover, an additional role for TF overexpression and subsequent generation of TF:FVIIa complex, FXa and thrombin have been recently emerged, contributing in non-thrombotic manifestations such as inflammation, cancer growth and fibrosis.The multivalent role of TF and the above mentioned proteases in disease is reviewed, with focus on their implication in non-thrombotic disorders, as suggested by clinical and experimental data. Moreover, potential therapeutic interventions using anticoagulation agents are discussed.A better understanding of the pathogenic role of the TF-thrombin pathway in the pathogenesis of disease and the effect of anticoagulants in the treatment of such disorders.The TF-thrombin pathway, apart from the initiation of hemostasis and thrombosis, exert intracellular signaling activity through protease-activated receptors, participating in inflammation and tumor biology. Both low-molecular-weight heparins and recently developed anticoagulants rise as candidates for the modification of biological functions associated with disorders like sepsis, ischemia-reperfusion or cancer growth and metastasis." @default.
- W2070794927 created "2016-06-24" @default.
- W2070794927 creator A5054545430 @default.
- W2070794927 creator A5059888183 @default.
- W2070794927 creator A5069152790 @default.
- W2070794927 creator A5079707370 @default.
- W2070794927 creator A5088141005 @default.
- W2070794927 date "2010-11-10" @default.
- W2070794927 modified "2023-10-18" @default.
- W2070794927 title "The multivalent activity of the tissue factor–thrombin pathway in thrombotic and non-thrombotic disorders as a target for therapeutic intervention" @default.
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