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• W2070794943 abstract "Lobular carcinoma in situ (LCIS) is the neglected step-child of breast cancer research. This is due in part to its rarity, but also in no small measure due to complacency: we thought we knew what to do about it. The consensus view for many years has been that LCIS is a marker of elevated risk of subsequent breast cancer development which is roughly equal in the ipsilateral and contralateral breast [1]. Most invasive cancers that will develop on either side will have ductal histology. Hence, the only local treatment required is a biopsy sufficiently large and well-examined by the pathologist to be certain that there was no ductal carcinoma in situ (DCIS) or invasive cancer present. Chemoprophylaxis has been shown to be effective in reducing the risk of future cancers in patients with LCIS [2], but certainly radiation therapy was not felt to play a role in their treatment. In recent years, ‘‘pleomorphic’’ LCIS and carcinomas in situ with mixed ductal and lobular features have been recognised as being separate entities from ‘‘classic’’ LCIS; they behave like DCIS and should be treated accordingly [3,4]. Still, LCIS sensu strictu remained boring. This idea that the index LCIS can basically be ignored has been challenged intermittently. A study by the Danish Breast Cancer Group found that 17% of 88 patients with either LCIS or mixed LCIS–DCIS developed ipsilateral invasive cancer or mixed DCIS– LCIS with a median follow-up time of 61 months; no contralateral cancers occurred [5]. Further, there were no differences in the ipsilateral breast tumour recur-" @default.
• W2070794943 created "2016-06-24" @default.
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• W2070794943 date "2005-02-01" @default.
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• W2070794943 title "Should patients with lobular carcinoma in situ be irradiated? – not yet, but...." @default.
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• W2070794943 doi "https://doi.org/10.1016/j.ejca.2004.10.009" @default.
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