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- W2070796772 abstract "Hydroxylamine produces significant levels of chromosomal breakage in plant and animal cells. Pursuant to treatment of plant root cells with this agent is the observation of little or no reunion of broken chromosome ends. The nature of the cytological effects of hydroxylamine has made it possible to study its influence on the production and rejoining of X-ray-induced chromosomal breaks. Lateral roots of Viccia faba were treated with 10−3 M hydroxylamine alone and in combination with X-rays, including fractionated dose exposures. Hydroxylamine was employed in a phosphate buffer at pH 6.75, and administered to the roots for one hour. Analyses of chromatid breaks and aberrations at metaphase of mitosis were made with respect to their frequencies and to the patterns of reunion of the broken ends. A few chromosome-type aberrations were observed. An apparently synergistic effect is produced by combined treatment, and, of greater significance, the reunion of broken ends of chromosomes is reduced considerably below that found with X-ray treatment alone. Reunion of isochromatid deletions was confined to either the distal (SUd) or proximal (SUp) ends, with many showing no reunion (NUpd). Of particular interest was the absence of complete reunion in a number of exchange aberrations. When a dose of 200 R was divided into two equal fractions of 100 R each and separated by an interval of one hour, differences in aberration frequencies were observed according to the conditions imposed during the interval. The presence of hydroxylamine between the two doses gave rise to an aberration frequency considerably higher than that found when the roots were held in water between X-ray exposures. This result provides strong support for the conclusion that hydroxylamine inhibits the rejoining events. Hydroxylamine, therefore not only causes chromosomal breaks, but also inhibts their rejoining. The mechanism of rejoining inhibition may involve some alteration of enzyme activity necessary for restitution and reunion and/or an impairement of DNA synthesis but no direct information is yet available to support these possibilities." @default.
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- W2070796772 date "1964-12-01" @default.
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- W2070796772 title "The effect of hydroxylamine on the rejoining of X-ray-induced chromatid breaks in Vicia faba" @default.
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- W2070796772 doi "https://doi.org/10.1016/0027-5107(64)90034-x" @default.
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