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- W2070797744 abstract "The monoclonal antibody (MAb) RWS4 specific to membrane-associated antigen of human gastric adenocarcinoma was purified by protein A-Sepharose 4B affinity chromatography and labeled with131I by chloramine-T method.131I-RWS4 was injected (65 µCi/10µg/0.2 ml, intraperitoneally) into the stomach cancer-bearing nude mice (solid tumor about 1 cm in diameter), and its biodistribution was studied by SPECT and gamma-counter over a peroid of 7 days. A clear image of transplanted tumor was observed on the 4th day, and the image became more clear on the 6th day. After SPECT scanning, the animals were killed on the 3rd to 7th day separately and radioactivity was detected in various organs. The ratios of T/NT were calculated. The results were shown as follows: tumor/blood, was 3.41±0.29 on the 6th day and the tumor/other organs (liver, spleen, stomach, lung, heart, kidney and brain etc.) were>3. The specificity of the131I-rwS4 was 7.74±0.65." @default.
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- W2070797744 date "1990-09-01" @default.
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- W2070797744 title "Radioimmunolocalization of xenografted human gastric adenocarcinoma with131I-labeled monoclonal antibody RWS4 in nude mice" @default.
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- W2070797744 doi "https://doi.org/10.1007/bf02997231" @default.
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