FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070798220> ?p ?o ?g. }

• W2070798220 endingPage "425" @default.
• W2070798220 startingPage "419" @default.
• W2070798220 abstract "Leukemia inhibitory factor (LIF) appears important in the process of blastocyst implantation in primates. In the present study, we investigated the effect on pregnancy outcome of the administration of a monoclonal antibody (mAb) to recombinant human (rh) LIF (anti-LIF mAb) into the uterine cavity of mated female rhesus monkeys during the peri-implantation period.Two milligrams of either mouse mAb to rhLIF or isotype-matched immunoglobulin (Ig) was administered into the uterine cavity on estimated Day 5 or Day 8 after ovulation either through the vagina (n=33) or through the oviduct (n=29) of successfully mated females.There was a significant (p<.04) decline in pregnancy outcome in groups treated with anti-LIF mAb (8 pregnancies from 32 animals) compared with control animals (24 pregnancies from 30 animals). There was, however, no significant difference in pregnancy inhibition between a group of animals subjected to vaginal route treatment and a group of animals subjected to oviductal route treatment, as well as between a group subjected to anti-LIF mAb on Day 5 after ovulation and a group subjected to anti-LIF mAb on Day 8 after ovulation. No significant change was seen in the number of viable pregnancy in animals treated with 6 mg of anti-LIF mAb (5 pregnancies from 16 animals) compared with animals treated with 2 mg of anti-LIF mAb (8 pregnancies from 32 animals). Serum profiles of estradiol, progesterone, monkey chorionic gonadotropin and mouse IgG did not show any difference among different treatment subgroups during the luteal phase. However, among animals treated with anti-LIF mAb, the mean area under the curve for serum mouse IgG in pregnant animals (234+/-55 microg/mL day) was significantly (p<.01) less than that of nonpregnant animals (1325+/-97 microg/mL day).The results of the present study put forward the proof of concept that LIF plays a critical role in the process of blastocyst implantation in the rhesus monkey." @default.
• W2070798220 created "2016-06-24" @default.
• W2070798220 creator A5006639639 @default.
• W2070798220 creator A5008848360 @default.
• W2070798220 creator A5058358017 @default.
• W2070798220 creator A5076238135 @default.
• W2070798220 date "2006-11-01" @default.
• W2070798220 modified "2023-09-27" @default.
• W2070798220 title "Monoclonal anti-leukemia inhibitory factor antibody inhibits blastocyst implantation in the rhesus monkey" @default.
• W2070798220 cites W1964764413 @default.
• W2070798220 cites W1966981219 @default.
• W2070798220 cites W1976270126 @default.
• W2070798220 cites W1980790915 @default.
• W2070798220 cites W1994152375 @default.
• W2070798220 cites W1998569665 @default.
• W2070798220 cites W1998638951 @default.
• W2070798220 cites W2004090646 @default.
• W2070798220 cites W2015041766 @default.
• W2070798220 cites W2019074062 @default.
• W2070798220 cites W2020492890 @default.
• W2070798220 cites W2023306710 @default.
• W2070798220 cites W2027464280 @default.
• W2070798220 cites W2039065568 @default.
• W2070798220 cites W2043894719 @default.
• W2070798220 cites W2044155412 @default.
• W2070798220 cites W2057454317 @default.
• W2070798220 cites W2058085780 @default.
• W2070798220 cites W2071104480 @default.
• W2070798220 cites W2074336725 @default.
• W2070798220 cites W2099860198 @default.
• W2070798220 cites W2109639589 @default.
• W2070798220 cites W2115395371 @default.
• W2070798220 cites W2117512917 @default.
• W2070798220 cites W2125415295 @default.
• W2070798220 cites W2130727765 @default.
• W2070798220 cites W2133531826 @default.
• W2070798220 cites W2133957937 @default.
• W2070798220 cites W2139836106 @default.
• W2070798220 cites W2143554821 @default.
• W2070798220 cites W2146473386 @default.
• W2070798220 cites W2147816968 @default.
• W2070798220 cites W2166877247 @default.
• W2070798220 cites W2314000972 @default.
• W2070798220 cites W2417739327 @default.
• W2070798220 cites W4239965704 @default.
• W2070798220 doi "https://doi.org/10.1016/j.contraception.2006.05.070" @default.
• W2070798220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17046385" @default.
• W2070798220 hasPublicationYear "2006" @default.
• W2070798220 type Work @default.
• W2070798220 sameAs 2070798220 @default.
• W2070798220 citedByCount "29" @default.
• W2070798220 countsByYear W20707982202012 @default.
• W2070798220 countsByYear W20707982202013 @default.
• W2070798220 countsByYear W20707982202014 @default.
• W2070798220 countsByYear W20707982202015 @default.
• W2070798220 countsByYear W20707982202016 @default.
• W2070798220 countsByYear W20707982202017 @default.
• W2070798220 countsByYear W20707982202020 @default.
• W2070798220 countsByYear W20707982202021 @default.
• W2070798220 countsByYear W20707982202022 @default.
• W2070798220 crossrefType "journal-article" @default.
• W2070798220 hasAuthorship W2070798220A5006639639 @default.
• W2070798220 hasAuthorship W2070798220A5008848360 @default.
• W2070798220 hasAuthorship W2070798220A5058358017 @default.
• W2070798220 hasAuthorship W2070798220A5076238135 @default.
• W2070798220 hasConcept C11988809 @default.
• W2070798220 hasConcept C126322002 @default.
• W2070798220 hasConcept C134018914 @default.
• W2070798220 hasConcept C143228043 @default.
• W2070798220 hasConcept C159654299 @default.
• W2070798220 hasConcept C16685009 @default.
• W2070798220 hasConcept C196843134 @default.
• W2070798220 hasConcept C203014093 @default.
• W2070798220 hasConcept C27284151 @default.
• W2070798220 hasConcept C2777702977 @default.
• W2070798220 hasConcept C2778177303 @default.
• W2070798220 hasConcept C2778690821 @default.
• W2070798220 hasConcept C2779234561 @default.
• W2070798220 hasConcept C542903549 @default.
• W2070798220 hasConcept C54355233 @default.
• W2070798220 hasConcept C71315377 @default.
• W2070798220 hasConcept C71924100 @default.
• W2070798220 hasConcept C86803240 @default.
• W2070798220 hasConcept C87073359 @default.
• W2070798220 hasConcept C95444343 @default.
• W2070798220 hasConceptScore W2070798220C11988809 @default.
• W2070798220 hasConceptScore W2070798220C126322002 @default.
• W2070798220 hasConceptScore W2070798220C134018914 @default.
• W2070798220 hasConceptScore W2070798220C143228043 @default.
• W2070798220 hasConceptScore W2070798220C159654299 @default.
• W2070798220 hasConceptScore W2070798220C16685009 @default.
• W2070798220 hasConceptScore W2070798220C196843134 @default.
• W2070798220 hasConceptScore W2070798220C203014093 @default.
• W2070798220 hasConceptScore W2070798220C27284151 @default.
• W2070798220 hasConceptScore W2070798220C2777702977 @default.
• W2070798220 hasConceptScore W2070798220C2778177303 @default.
• W2070798220 hasConceptScore W2070798220C2778690821 @default.
• W2070798220 hasConceptScore W2070798220C2779234561 @default.

• next