Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070804934> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2070804934 endingPage "283" @default.
- W2070804934 startingPage "279" @default.
- W2070804934 abstract "From February 1995 through October 1996, 25 patients with metastatic colorectal cancer showing a clinical resistance to 5-fluorouracil (5-FU) entered this study. Thirteen received oxaliplatin alone and 12 received it in combination with 5-FU. Oxaliplatin was administered at 130 mg/m2 over a 2-hour infusion every 3 weeks, alone or added either to 5-FU as a continuous infusion at 200 mg/m2 to 300 mg/m2 (six patients) or to a 5-FU bolus, 375 mg/m2, plus leucovorin, 100 mg/m2, daily for 5 days every 3 weeks (6 patients). Eighty-six of 98 administered cycles were evaluable for toxicity (47 for oxaliplatin plus 5-FU and 39 for oxaliplatin alone). Hematologic toxicity was mild, occurring as grade 2 leukopenia in 23% of the cycles of 5-FU and oxaliplatin and in 5% of the cycles of oxaliplatin alone. The most common toxicity was neurologic (grade 1 to 2 in 60%-6% of the cycles of the combination, respectively, and 68%-10% of oxaliplatin given alone) as hand-foot paresthesia or hypersensitivity to cold. No grade 4 toxicity was reported and only three patients in the 5-FU group developed grade 3 diarrhea. Grade 2 nausea and vomiting occurred in 33% of the cycles when both drugs were given and in 15% when oxaliplatin was administered alone. The combination of oxaliplatin and 5-FU induced four partial remissions (33%; 95% confidence interval, 6%-60%), whereas eight patients of the whole group had stable disease. No response occurred when oxaliplatin was administered as a single agent. The results of this study confirm the antitumor activity of oxaliplatin when added to 5-FU in patients who have metastatic colorectal cancer previously refractory to 5-FU. The possible therapeutic synergy with 5-FU was not accompanied by increased toxicity." @default.
- W2070804934 created "2016-06-24" @default.
- W2070804934 creator A5011160865 @default.
- W2070804934 creator A5011430989 @default.
- W2070804934 creator A5016743667 @default.
- W2070804934 creator A5033285318 @default.
- W2070804934 creator A5038355731 @default.
- W2070804934 creator A5062234802 @default.
- W2070804934 creator A5084629809 @default.
- W2070804934 date "1998-06-01" @default.
- W2070804934 modified "2023-10-18" @default.
- W2070804934 title "Synergistic Activity of Oxaliplatin and 5-Fluorouracil in Patients With Metastatic Colorectal Cancer With Progressive Disease While on or After 5-Fluorouracil" @default.
- W2070804934 cites W1974483480 @default.
- W2070804934 cites W1996167718 @default.
- W2070804934 cites W2032171886 @default.
- W2070804934 cites W2033465919 @default.
- W2070804934 cites W2051071188 @default.
- W2070804934 cites W2052457410 @default.
- W2070804934 cites W2059234543 @default.
- W2070804934 cites W2253033732 @default.
- W2070804934 cites W2602544133 @default.
- W2070804934 cites W4238668552 @default.
- W2070804934 doi "https://doi.org/10.1097/00000421-199806000-00015" @default.
- W2070804934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9626798" @default.
- W2070804934 hasPublicationYear "1998" @default.
- W2070804934 type Work @default.
- W2070804934 sameAs 2070804934 @default.
- W2070804934 citedByCount "36" @default.
- W2070804934 countsByYear W20708049342013 @default.
- W2070804934 countsByYear W20708049342014 @default.
- W2070804934 countsByYear W20708049342015 @default.
- W2070804934 countsByYear W20708049342016 @default.
- W2070804934 countsByYear W20708049342018 @default.
- W2070804934 countsByYear W20708049342019 @default.
- W2070804934 countsByYear W20708049342020 @default.
- W2070804934 countsByYear W20708049342022 @default.
- W2070804934 countsByYear W20708049342023 @default.
- W2070804934 crossrefType "journal-article" @default.
- W2070804934 hasAuthorship W2070804934A5011160865 @default.
- W2070804934 hasAuthorship W2070804934A5011430989 @default.
- W2070804934 hasAuthorship W2070804934A5016743667 @default.
- W2070804934 hasAuthorship W2070804934A5033285318 @default.
- W2070804934 hasAuthorship W2070804934A5038355731 @default.
- W2070804934 hasAuthorship W2070804934A5062234802 @default.
- W2070804934 hasAuthorship W2070804934A5084629809 @default.
- W2070804934 hasBestOaLocation W20708049342 @default.
- W2070804934 hasConcept C121608353 @default.
- W2070804934 hasConcept C126322002 @default.
- W2070804934 hasConcept C141071460 @default.
- W2070804934 hasConcept C2776694085 @default.
- W2070804934 hasConcept C2778822529 @default.
- W2070804934 hasConcept C2780456651 @default.
- W2070804934 hasConcept C2780580376 @default.
- W2070804934 hasConcept C2780852908 @default.
- W2070804934 hasConcept C2780873365 @default.
- W2070804934 hasConcept C2780962732 @default.
- W2070804934 hasConcept C29730261 @default.
- W2070804934 hasConcept C43376680 @default.
- W2070804934 hasConcept C526805850 @default.
- W2070804934 hasConcept C71924100 @default.
- W2070804934 hasConcept C90924648 @default.
- W2070804934 hasConceptScore W2070804934C121608353 @default.
- W2070804934 hasConceptScore W2070804934C126322002 @default.
- W2070804934 hasConceptScore W2070804934C141071460 @default.
- W2070804934 hasConceptScore W2070804934C2776694085 @default.
- W2070804934 hasConceptScore W2070804934C2778822529 @default.
- W2070804934 hasConceptScore W2070804934C2780456651 @default.
- W2070804934 hasConceptScore W2070804934C2780580376 @default.
- W2070804934 hasConceptScore W2070804934C2780852908 @default.
- W2070804934 hasConceptScore W2070804934C2780873365 @default.
- W2070804934 hasConceptScore W2070804934C2780962732 @default.
- W2070804934 hasConceptScore W2070804934C29730261 @default.
- W2070804934 hasConceptScore W2070804934C43376680 @default.
- W2070804934 hasConceptScore W2070804934C526805850 @default.
- W2070804934 hasConceptScore W2070804934C71924100 @default.
- W2070804934 hasConceptScore W2070804934C90924648 @default.
- W2070804934 hasIssue "3" @default.
- W2070804934 hasLocation W20708049341 @default.
- W2070804934 hasLocation W20708049342 @default.
- W2070804934 hasLocation W20708049343 @default.
- W2070804934 hasOpenAccess W2070804934 @default.
- W2070804934 hasPrimaryLocation W20708049341 @default.
- W2070804934 hasRelatedWork W177976942 @default.
- W2070804934 hasRelatedWork W1997778569 @default.
- W2070804934 hasRelatedWork W2348071463 @default.
- W2070804934 hasRelatedWork W2358719358 @default.
- W2070804934 hasRelatedWork W2364358549 @default.
- W2070804934 hasRelatedWork W2385249822 @default.
- W2070804934 hasRelatedWork W2424894649 @default.
- W2070804934 hasRelatedWork W2903876151 @default.
- W2070804934 hasRelatedWork W595487296 @default.
- W2070804934 hasRelatedWork W2521740187 @default.
- W2070804934 hasVolume "21" @default.
- W2070804934 isParatext "false" @default.
- W2070804934 isRetracted "false" @default.
- W2070804934 magId "2070804934" @default.
- W2070804934 workType "article" @default.