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- W2070808213 abstract "Abstract Recent reports suggest that carcinogenicity of hydrogen peroxide (H 2 O 2 ) is implicated in inhibition of gap junction intercellular communication (GJIC), which is a cellular event associated with the tumor promotion. The present study investigated the effect of phenolics (KF) from leaves of Abies nephrolepis (Khingan fir) on inhibition of GJIC by H 2 O 2 in WB‐F344 rat liver epithelial cells. The phenolics were extracted from fresh leaves by using 80% aqueous methanol, and were analyzed mainly as catechin derivatives including epigallocatechin gallate (EGCG) and catechin itself. KF and EGCG protected the inhibition of GJIC by H 2 O 2 , whereas butylated hydroxytoluene, a commercial antioxidant, had no effect. Our results indicate that KF exhibits potential chemopreventive effects against carcinogenesis, which may be attributable to phenolics such as EGCG." @default.
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- W2070808213 date "2004-01-01" @default.
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- W2070808213 title "<i>Abies nephrolepis</i> leaf phenolics prevent the inhibition of gap junction intercellular communication by hydrogen peroxide in rat liver epithelial cells" @default.
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- W2070808213 doi "https://doi.org/10.1002/biof.552210168" @default.
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