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- W2070815725 abstract "2′,5′-Dideoxyadenosine 3′-di- and triphosphates were tested as inhibitors of brain adenylyl cyclases. With an IC50 ∼40 nM, 2′,5′-dideoxy-3′-ATP is the most potent non-protein synthetic regulator of adenylyl cyclases thus far described. Neither 2′,5′-dideoxy-3′-ADP nor 2′,5′-dideoxy-3′-ATP inhibited activity by competition with substrate, and the linear noncompetitive inhibition observed was consistent with interaction via a distinct domain. The availability of this ligand will permit the development of a variety of probes that will be extremely useful in investigating adenylyl cyclase structure and the role(s) that this class of compound may play in physiologically regulating cell function. 2′,5′-Dideoxyadenosine 3′-di- and triphosphates were tested as inhibitors of brain adenylyl cyclases. With an IC50 ∼40 nM, 2′,5′-dideoxy-3′-ATP is the most potent non-protein synthetic regulator of adenylyl cyclases thus far described. Neither 2′,5′-dideoxy-3′-ADP nor 2′,5′-dideoxy-3′-ATP inhibited activity by competition with substrate, and the linear noncompetitive inhibition observed was consistent with interaction via a distinct domain. The availability of this ligand will permit the development of a variety of probes that will be extremely useful in investigating adenylyl cyclase structure and the role(s) that this class of compound may play in physiologically regulating cell function." @default.
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- W2070815725 date "1996-02-01" @default.
- W2070815725 modified "2023-10-15" @default.
- W2070815725 title "2′,5′-Dideoxyadenosine 3′-Polyphosphates Are Potent Inhibitors of Adenylyl Cyclases" @default.
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- W2070815725 doi "https://doi.org/10.1074/jbc.271.5.2380" @default.
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