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- W2070837309 abstract "Abstract Unusual HLA‐A ‘null’ alleles because of an entire gene deletion were found in three apparently unrelated Japanese families with leukemia patients. Inclusion of the entire HLA‐A gene in the deletion was confirmed by polymerase chain reaction direct sequencing of the surrounding regions of HLA‐A . Further localization of the breakpoints of the HLA‐A deletion at the centromeric and telomeric sides was performed, and these families were shown to possess the identical deletion. We then determined the genomic sequence of the HLA‐A ‐deleted haplotype. Surprisingly, the haplotype turned out to carry an insertion of an SVA (SINE‐VNTR‐ Alu ) retrotransposon of 2 kb as well as the 14 kb deletion that included the entire HLA‐A gene." @default.
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- W2070837309 date "2007-06-30" @default.
- W2070837309 modified "2023-10-15" @default.
- W2070837309 title "Deletion of entire HLA-A gene accompanied by an insertion of a retrotransposon" @default.
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- W2070837309 doi "https://doi.org/10.1111/j.1399-0039.2007.00870.x" @default.
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