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• W2070856502 abstract "Both multiple sclerosis (MS) susceptibility and MS clinical phenotype are in part genetically determined. [Alpha]B-crystallin is a candidate autoantigen in MS, and there are three polymorphisms in the promoter region of the encoding gene (CRYAB): at positions -C249G, -C650G, and -A652G.These polymorphisms were studied in sporadic cases of MS, assessing disease susceptibility, clinical phenotype, and MRI appearance.The CRYAB polymorphisms influenced susceptibility as well as disease expression in MS.Carriers of the rare allele CRYAB-650*C had an increased likelihood of a noninflammatory, neurodegenerative phenotype characterized by a relatively rapid, primary progressive clinical disease course." @default.
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• W2070856502 date "2003-11-10" @default.
• W2070856502 modified "2023-09-23" @default.
• W2070856502 title " B-Crystallin genotype has impact on the multiple sclerosis phenotype" @default.
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• W2070856502 doi "https://doi.org/10.1212/01.wnl.0000091861.27246.9e" @default.
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