Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070863313> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2070863313 endingPage "854" @default.
- W2070863313 startingPage "849" @default.
- W2070863313 abstract "The effect of the catatoxic steroid, 3β-hydroxy-20-oxo-5-pregnene-16α-carbonitrile [pregnenolone-16α-carbonitrile (PCN)] on hepatic microsomal cholesterol-7α-hydroxylase, the probable rate-limiting enzyme of bile acid biosynthesis, has been studied. Short term administration (3 days) of PCN in the diet of rats resulted in a significant decrease in the liver microsomal cholesterol-7α-hydroxylase activity, in contrast to a marked stimulation of microsomal cytochrome P-450 and ethylmorphine demethylase activity. PCN significantly depressed the cholesterol-7α-hydroxylase activity in the livers of rats with elevated levels of the enzyme produced by cholestyramine feeding. The results indicate the presence of separate control mechanisms in the regulation of bile acid synthesis and drug metabolism." @default.
- W2070863313 created "2016-06-24" @default.
- W2070863313 creator A5026136650 @default.
- W2070863313 creator A5063152677 @default.
- W2070863313 date "1978-06-01" @default.
- W2070863313 modified "2023-09-24" @default.
- W2070863313 title "The suppressive effect of the catatoxic steroid, pregnenolone-16α-carbonitrile, on liver microsomal cholesterol-7α-hydroxylase" @default.
- W2070863313 cites W1608750224 @default.
- W2070863313 cites W1806194750 @default.
- W2070863313 cites W1951469402 @default.
- W2070863313 cites W1984246888 @default.
- W2070863313 cites W1990811403 @default.
- W2070863313 cites W2003801590 @default.
- W2070863313 cites W2037232177 @default.
- W2070863313 cites W2059316380 @default.
- W2070863313 cites W2073574286 @default.
- W2070863313 cites W2183371354 @default.
- W2070863313 cites W2011135418 @default.
- W2070863313 doi "https://doi.org/10.1016/s0039-128x(78)80048-8" @default.
- W2070863313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/694973" @default.
- W2070863313 hasPublicationYear "1978" @default.
- W2070863313 type Work @default.
- W2070863313 sameAs 2070863313 @default.
- W2070863313 citedByCount "8" @default.
- W2070863313 countsByYear W20708633132013 @default.
- W2070863313 countsByYear W20708633132015 @default.
- W2070863313 countsByYear W20708633132017 @default.
- W2070863313 crossrefType "journal-article" @default.
- W2070863313 hasAuthorship W2070863313A5026136650 @default.
- W2070863313 hasAuthorship W2070863313A5063152677 @default.
- W2070863313 hasConcept C126322002 @default.
- W2070863313 hasConcept C134018914 @default.
- W2070863313 hasConcept C181199279 @default.
- W2070863313 hasConcept C185592680 @default.
- W2070863313 hasConcept C24998067 @default.
- W2070863313 hasConcept C2778163477 @default.
- W2070863313 hasConcept C2778697171 @default.
- W2070863313 hasConcept C2780193516 @default.
- W2070863313 hasConcept C2780361610 @default.
- W2070863313 hasConcept C2780753045 @default.
- W2070863313 hasConcept C2780902042 @default.
- W2070863313 hasConcept C553450214 @default.
- W2070863313 hasConcept C55493867 @default.
- W2070863313 hasConcept C71315377 @default.
- W2070863313 hasConcept C71924100 @default.
- W2070863313 hasConcept C86803240 @default.
- W2070863313 hasConcept C87644729 @default.
- W2070863313 hasConcept C89673097 @default.
- W2070863313 hasConceptScore W2070863313C126322002 @default.
- W2070863313 hasConceptScore W2070863313C134018914 @default.
- W2070863313 hasConceptScore W2070863313C181199279 @default.
- W2070863313 hasConceptScore W2070863313C185592680 @default.
- W2070863313 hasConceptScore W2070863313C24998067 @default.
- W2070863313 hasConceptScore W2070863313C2778163477 @default.
- W2070863313 hasConceptScore W2070863313C2778697171 @default.
- W2070863313 hasConceptScore W2070863313C2780193516 @default.
- W2070863313 hasConceptScore W2070863313C2780361610 @default.
- W2070863313 hasConceptScore W2070863313C2780753045 @default.
- W2070863313 hasConceptScore W2070863313C2780902042 @default.
- W2070863313 hasConceptScore W2070863313C553450214 @default.
- W2070863313 hasConceptScore W2070863313C55493867 @default.
- W2070863313 hasConceptScore W2070863313C71315377 @default.
- W2070863313 hasConceptScore W2070863313C71924100 @default.
- W2070863313 hasConceptScore W2070863313C86803240 @default.
- W2070863313 hasConceptScore W2070863313C87644729 @default.
- W2070863313 hasConceptScore W2070863313C89673097 @default.
- W2070863313 hasIssue "6" @default.
- W2070863313 hasLocation W20708633131 @default.
- W2070863313 hasLocation W20708633132 @default.
- W2070863313 hasOpenAccess W2070863313 @default.
- W2070863313 hasPrimaryLocation W20708633131 @default.
- W2070863313 hasRelatedWork W1987039281 @default.
- W2070863313 hasRelatedWork W1987914672 @default.
- W2070863313 hasRelatedWork W2013662683 @default.
- W2070863313 hasRelatedWork W2022232240 @default.
- W2070863313 hasRelatedWork W2056726781 @default.
- W2070863313 hasRelatedWork W2062452627 @default.
- W2070863313 hasRelatedWork W2070863313 @default.
- W2070863313 hasRelatedWork W2108286282 @default.
- W2070863313 hasRelatedWork W2326282748 @default.
- W2070863313 hasRelatedWork W1728840267 @default.
- W2070863313 hasVolume "31" @default.
- W2070863313 isParatext "false" @default.
- W2070863313 isRetracted "false" @default.
- W2070863313 magId "2070863313" @default.
- W2070863313 workType "article" @default.