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- W2070865177 abstract "The effect of an endogenous uncoupler from rat liver on oxidative phosphorylation of mitochondria in the liver, kidney, heart, lung, and brain was investigated. Its action was shown to be tissue-specific. The selectivity of the action of the uncoupling factor on the mitochondrial membrane is manifested best at pH values from 6.3 to 6.9, close to those in the cytoplasm of the liver. Tissue specificity is independent of the initial state of the mitochondria within wide limits and it can abolished only by thermal injury to oxidative phosphorylation. Activity of the tissue-specific uncoupler is not reduced by sedimentation of ribosomes and microsomes. The addition of bovine albumin to the incubation medium does not affect the degree of tissue-specific uncoupling. The role of the uncoupler in the regulation of proliferation within the tissue is postulated." @default.
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- W2070865177 date "1977-07-01" @default.
- W2070865177 modified "2023-09-23" @default.
- W2070865177 title "A tissue-specific uncoupler of mitochondrial oxidative phosphorylation" @default.
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- W2070865177 doi "https://doi.org/10.1007/bf00798515" @default.
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