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- W2070868863 endingPage "3036" @default.
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- W2070868863 abstract "A surface probability method was used to select a decapeptide homologous to residues 993 to 1002 of the peplomer protein E2 of murine hepatitis virus strain JHM, a neurotropic coronavirus. This sequence of amino acids corresponded to a minor peak on a hydrophilicity plot. Immunization of mice with the chemically synthesized peptide coupled to keyhole limpet hemocyanin elicited high levels of neutralizing antibody and protected against lethal virus challenge. Protection correlated with a critical level of antipeptide antibody, which could be reached after a single inoculation. These results suggest that an appropriate antibody response to a highly restricted, surface-exposed domain of this viral protein is critical in determining the outcome of infection of the central nervous system. This sequence is located in the C-terminal fifth of the E2 peplomers, between two predicted coiled-coil structures." @default.
- W2070868863 created "2016-06-24" @default.
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- W2070868863 date "1988-08-01" @default.
- W2070868863 modified "2023-10-01" @default.
- W2070868863 title "Vaccination against lethal coronavirus-induced encephalitis with a synthetic decapeptide homologous to a domain in the predicted peplomer stalk" @default.
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- W2070868863 doi "https://doi.org/10.1128/jvi.62.8.3032-3036.1988" @default.
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