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• W2070873807 abstract "A biodegradable polymer, poly(d,l-lactide-co-glycolide) RESOMER® RG756, was modified by surface immobilization of recombinant hirudin (r-Hir) with glutaraldehyde as coupling reagent to improve the blood contacting properties of the polymer. The activity of immobilized hirudin on the polymer was estimated by a chromogenic assay to about 2.5 ATU r-Hir cm−2. The improvement of the haemocompatibility of the modified RG756 was evaluated in terms of platelet adhesion/activation, whole blood clotting times and clot formation rate. Fluorescence microscopy revealed that surface modification with r-Hir resulted in decreased platelet adhesion and activation. An ELISA for P-selectin, a marker of platelet activation, was used to confirm this result. Clotting time experiments demonstrated significantly prolonged non-activated partial thromboplastin times, and a decreased clot formation rate of whole blood in contact with r-Hir modified RG756 compared with the plain polymer. Comparison of immobilized r-Hir with bound heparin yielded equivalent improvement of blood-contacting properties of the investigated polymers. These in vitro investigations indicate that the immobilization of r-Hir on RG756 is a useful method to improve the blood contacting properties of polylactides/polyglycolides and other polymers as well." @default.
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• W2070873807 date "1997-01-01" @default.
• W2070873807 modified "2023-10-06" @default.
• W2070873807 title "Covalent immobilization of hirudin improves the haemocompatibility of polylactide—polyglycolide in vitro" @default.
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• W2070873807 doi "https://doi.org/10.1016/s0142-9612(97)00079-3" @default.
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