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- W2070877290 abstract "Multiple lines of evidence show that oxidation products of ascorbic acid (vitamin C) are capable of inducing a variety of genetic alterations in microbial and mammalian cells. We have studied the inactivation kinetics in repair proficient and deficient Escherichia coli K12 cells treated with oxidized solutions of ascorbic acid, in the presence of catalytic amounts of copper. Our results suggest that the repair pathways controlled by the rec A and uvr A gene products (the latter in a rec A strain) contribute to cell survival. However, the lack of β-galactosidase induction, in the SOS chromotest, implies a role for the RecA protein other than SOS induction. Catalase and thiourea suppress the toxic effects of oxidized ascorbate solutions, confirming that H 2 O 2 and hydroxyl radicals are intermediate agents in the damaging action. Single-strand breaks were detected in DNA from treated cells." @default.
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- W2070877290 date "1986-01-01" @default.
- W2070877290 modified "2023-09-26" @default.
- W2070877290 title "Ascorbate-copper induced DNA lesions and repair in Escherichia coli K12 cells" @default.
- W2070877290 doi "https://doi.org/10.1093/carcin/7.2.197" @default.
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