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• W2070878566 abstract "The maternal morphogen Bicoid (Bcd) is distributed in an embryonic gradient that is critical for patterning the anterior-posterior (AP) body plan in Drosophila. Previous work identified several target genes that respond directly to Bcd-dependent activation. Positioning of these targets along the AP axis is thought to be controlled by cis-regulatory modules (CRMs) that contain clusters of Bcd-binding sites of different strengths. Here we use a combination of Bcd-site cluster analysis and evolutionary conservation to predict Bcd-dependent CRMs. We tested 14 predicted CRMs by in vivo reporter gene assays; 11 show Bcd-dependent activation, which brings the total number of known Bcd target elements to 21. Some CRMs drive expression patterns that are restricted to the most anterior part of the embryo, whereas others extend into middle and posterior regions. However, we do not detect a strong correlation between AP position of target gene expression and the strength of Bcd site clusters alone. Rather, we find that binding sites for other activators, including Hunchback and Caudal correlate with CRM expression in middle and posterior body regions. Also, many Bcd-dependent CRMs contain clusters of sites for the gap protein Kruppel, which may limit the posterior extent of activation by the Bcd gradient. We propose that the key design principle in AP patterning is the differential integration of positive and negative transcriptional information at the level of individual CRMs for each target gene." @default.
• W2070878566 created "2016-06-24" @default.
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• W2070878566 date "2005-03-25" @default.
• W2070878566 modified "2023-09-23" @default.
• W2070878566 title "The role of binding site cluster strength in Bicoid-dependent patterning in <i>Drosophila</i>" @default.
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• W2070878566 doi "https://doi.org/10.1073/pnas.0500373102" @default.
• W2070878566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/555997" @default.
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