Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070884539> ?p ?o ?g. }
- W2070884539 endingPage "77" @default.
- W2070884539 startingPage "70" @default.
- W2070884539 abstract "Somatostatin-14 was discovered in 1973 in the hypothalamus as a peptide inhibiting growth hormone release. Somatostatin interacts with five receptor subtypes (sst1−5) which are widely distributed in the brain with a distinct, but overlapping, expression pattern. During the last few years, the development of highly selective peptide agonists and antagonists provided new insight to characterize the role of somatostatin receptor subtypes in the pleiotropic actions of somatostatin. Recent evidence in rodents indicates that the activation of selective somatostatin receptor subtypes in the brain blunts stress-corticotropin-releasing factor (CRF) related ACTH release (sst2/5), sympathetic-adrenal activaton (sst5), stimulation of colonic motility (sst1), delayed gastric emptying (sst5), suppression of food intake (sst2) and the anxiogenic-like (sst2) response. These findings suggest that brain somatostatin signaling pathways may play an important role in dampening CRF-mediated endocrine, sympathetic, behavioral and visceral responses to stress." @default.
- W2070884539 created "2016-06-24" @default.
- W2070884539 creator A5003830977 @default.
- W2070884539 creator A5010241733 @default.
- W2070884539 creator A5015430705 @default.
- W2070884539 date "2013-04-01" @default.
- W2070884539 modified "2023-10-03" @default.
- W2070884539 title "Modulation of the adaptive response to stress by brain activation of selective somatostatin receptor subtypes" @default.
- W2070884539 cites W1522976403 @default.
- W2070884539 cites W1529843839 @default.
- W2070884539 cites W1531765500 @default.
- W2070884539 cites W1597770416 @default.
- W2070884539 cites W1606465003 @default.
- W2070884539 cites W1821391444 @default.
- W2070884539 cites W1944472867 @default.
- W2070884539 cites W1960724759 @default.
- W2070884539 cites W1963803770 @default.
- W2070884539 cites W1964687670 @default.
- W2070884539 cites W1965023718 @default.
- W2070884539 cites W1965615942 @default.
- W2070884539 cites W1967818929 @default.
- W2070884539 cites W1968380453 @default.
- W2070884539 cites W1968407572 @default.
- W2070884539 cites W1968574868 @default.
- W2070884539 cites W1971878906 @default.
- W2070884539 cites W1971959365 @default.
- W2070884539 cites W1974653630 @default.
- W2070884539 cites W1975941894 @default.
- W2070884539 cites W1976261174 @default.
- W2070884539 cites W1976411170 @default.
- W2070884539 cites W1977084553 @default.
- W2070884539 cites W1980835732 @default.
- W2070884539 cites W1983310573 @default.
- W2070884539 cites W1984376648 @default.
- W2070884539 cites W1985841848 @default.
- W2070884539 cites W1989520943 @default.
- W2070884539 cites W1992726547 @default.
- W2070884539 cites W1992781436 @default.
- W2070884539 cites W1993152129 @default.
- W2070884539 cites W1996894796 @default.
- W2070884539 cites W1998976106 @default.
- W2070884539 cites W1999397021 @default.
- W2070884539 cites W2002389632 @default.
- W2070884539 cites W2003446134 @default.
- W2070884539 cites W2004133692 @default.
- W2070884539 cites W2007567221 @default.
- W2070884539 cites W2009248375 @default.
- W2070884539 cites W2010612215 @default.
- W2070884539 cites W2013745104 @default.
- W2070884539 cites W2014371484 @default.
- W2070884539 cites W2015187345 @default.
- W2070884539 cites W2016238598 @default.
- W2070884539 cites W2016368229 @default.
- W2070884539 cites W2017502291 @default.
- W2070884539 cites W2018282412 @default.
- W2070884539 cites W2019224452 @default.
- W2070884539 cites W2019572624 @default.
- W2070884539 cites W2021462854 @default.
- W2070884539 cites W2022006833 @default.
- W2070884539 cites W2022611329 @default.
- W2070884539 cites W2022685867 @default.
- W2070884539 cites W2028607195 @default.
- W2070884539 cites W2028792535 @default.
- W2070884539 cites W2031266705 @default.
- W2070884539 cites W2033893430 @default.
- W2070884539 cites W2036004953 @default.
- W2070884539 cites W2037930263 @default.
- W2070884539 cites W2040202620 @default.
- W2070884539 cites W2040329579 @default.
- W2070884539 cites W2041300217 @default.
- W2070884539 cites W2041303329 @default.
- W2070884539 cites W2045504208 @default.
- W2070884539 cites W2046811219 @default.
- W2070884539 cites W2048268520 @default.
- W2070884539 cites W2048785360 @default.
- W2070884539 cites W2050629955 @default.
- W2070884539 cites W2051625564 @default.
- W2070884539 cites W2052936788 @default.
- W2070884539 cites W2057935593 @default.
- W2070884539 cites W2058256587 @default.
- W2070884539 cites W2058601367 @default.
- W2070884539 cites W2058743289 @default.
- W2070884539 cites W2060488379 @default.
- W2070884539 cites W2063493635 @default.
- W2070884539 cites W2064910482 @default.
- W2070884539 cites W2067683441 @default.
- W2070884539 cites W2070476762 @default.
- W2070884539 cites W2071310612 @default.
- W2070884539 cites W2071699651 @default.
- W2070884539 cites W2075317954 @default.
- W2070884539 cites W2077373139 @default.
- W2070884539 cites W2078625410 @default.
- W2070884539 cites W2078786286 @default.
- W2070884539 cites W2079250210 @default.
- W2070884539 cites W2080232093 @default.
- W2070884539 cites W2093070695 @default.
- W2070884539 cites W2093645564 @default.
- W2070884539 cites W2112328205 @default.