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- W2070895853 endingPage "131" @default.
- W2070895853 startingPage "120" @default.
- W2070895853 abstract "A bstract : The pathogenesis of Parkinson's disease (PD) remains obscure, but there is increasing evidence that impairment of mitochondrial function, oxidative damage, and inflammation are contributing factors. The present paper reviews the experimental and clinical evidence implicating these processes in PD. There is substantial evidence that there is a deficiency of complex I activity of the mitochondrial electron transport chain in PD. There is also evidence for increased numbers of activated microglia in both PD postmortem tissue as well as in animal models of PD. Impaired mitochondrial function and activated microglia may both contribute to oxidative damage in PD. A number of therapies targeting inflammation and mitochondrial dysfunction are efficacious in the MPTP model of PD. Of these, coenzyme Q 10 appears to be particularly promising based on the results of a recent phase 2 clinical trial in which it significantly slowed the progression of PD." @default.
- W2070895853 created "2016-06-24" @default.
- W2070895853 creator A5040633232 @default.
- W2070895853 date "2003-06-01" @default.
- W2070895853 modified "2023-10-09" @default.
- W2070895853 title "Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease" @default.
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