FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070904831> ?p ?o ?g. }

• W2070904831 endingPage "15657" @default.
• W2070904831 startingPage "15656" @default.
• W2070904831 abstract "We report that lung cancer-targeting peptides isolated from a peptide library can be used to deliver an active chemotherapeutic in a cell-specific fashion. The peptides were removed from the context of the phage and placed on a pegylated tetrameric scaffold. The tetrameric peptides were shown to block uptake of their cognate phage. The tetrameric peptides were coupled to doxorubicin, and their cytotoxicity against a panel of different cell lines was tested. Our data demonstrate that these targeting peptides can deliver an active anticancer agent in a cell-specific fashion, resulting in an increase of the therapeutic index of the targeted drug compared to systemic delivery. The efficacy of the peptide conjugate correlates to the affinity of the targeting peptide for a particular cell line. As such, we have demonstrated that cell-specific targeted drugs can be synthesized, even when the cell surface target is unknown." @default.
• W2070904831 created "2016-06-24" @default.
• W2070904831 creator A5016717131 @default.
• W2070904831 creator A5020332410 @default.
• W2070904831 creator A5050920027 @default.
• W2070904831 creator A5056382164 @default.
• W2070904831 creator A5073126801 @default.
• W2070904831 date "2004-11-10" @default.
• W2070904831 modified "2023-10-16" @default.
• W2070904831 title "Cell-Specific Delivery of a Chemotherapeutic to Lung Cancer Cells" @default.
• W2070904831 cites W1505761689 @default.
• W2070904831 cites W1975096988 @default.
• W2070904831 cites W1994186346 @default.
• W2070904831 cites W1997826619 @default.
• W2070904831 cites W1998052952 @default.
• W2070904831 cites W2001728487 @default.
• W2070904831 cites W2008934533 @default.
• W2070904831 cites W2009909078 @default.
• W2070904831 cites W2031630601 @default.
• W2070904831 cites W2041109673 @default.
• W2070904831 cites W2042205576 @default.
• W2070904831 cites W2055832389 @default.
• W2070904831 cites W2061393217 @default.
• W2070904831 cites W2077639460 @default.
• W2070904831 cites W2141502931 @default.
• W2070904831 cites W2887646283 @default.
• W2070904831 doi "https://doi.org/10.1021/ja0446496" @default.
• W2070904831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15571383" @default.
• W2070904831 hasPublicationYear "2004" @default.
• W2070904831 type Work @default.
• W2070904831 sameAs 2070904831 @default.
• W2070904831 citedByCount "39" @default.
• W2070904831 countsByYear W20709048312012 @default.
• W2070904831 countsByYear W20709048312013 @default.
• W2070904831 countsByYear W20709048312014 @default.
• W2070904831 countsByYear W20709048312016 @default.
• W2070904831 countsByYear W20709048312017 @default.
• W2070904831 countsByYear W20709048312018 @default.
• W2070904831 countsByYear W20709048312019 @default.
• W2070904831 countsByYear W20709048312021 @default.
• W2070904831 crossrefType "journal-article" @default.
• W2070904831 hasAuthorship W2070904831A5016717131 @default.
• W2070904831 hasAuthorship W2070904831A5020332410 @default.
• W2070904831 hasAuthorship W2070904831A5050920027 @default.
• W2070904831 hasAuthorship W2070904831A5056382164 @default.
• W2070904831 hasAuthorship W2070904831A5073126801 @default.
• W2070904831 hasConcept C104317684 @default.
• W2070904831 hasConcept C109316439 @default.
• W2070904831 hasConcept C126511603 @default.
• W2070904831 hasConcept C134306372 @default.
• W2070904831 hasConcept C1491633281 @default.
• W2070904831 hasConcept C151730666 @default.
• W2070904831 hasConcept C167625842 @default.
• W2070904831 hasConcept C178790620 @default.
• W2070904831 hasConcept C185592680 @default.
• W2070904831 hasConcept C186268636 @default.
• W2070904831 hasConcept C197336794 @default.
• W2070904831 hasConcept C202751555 @default.
• W2070904831 hasConcept C2776471321 @default.
• W2070904831 hasConcept C2776694085 @default.
• W2070904831 hasConcept C2779281246 @default.
• W2070904831 hasConcept C2779343474 @default.
• W2070904831 hasConcept C2779820397 @default.
• W2070904831 hasConcept C2781303535 @default.
• W2070904831 hasConcept C33923547 @default.
• W2070904831 hasConcept C502942594 @default.
• W2070904831 hasConcept C54355233 @default.
• W2070904831 hasConcept C55493867 @default.
• W2070904831 hasConcept C81885089 @default.
• W2070904831 hasConcept C86803240 @default.
• W2070904831 hasConceptScore W2070904831C104317684 @default.
• W2070904831 hasConceptScore W2070904831C109316439 @default.
• W2070904831 hasConceptScore W2070904831C126511603 @default.
• W2070904831 hasConceptScore W2070904831C134306372 @default.
• W2070904831 hasConceptScore W2070904831C1491633281 @default.
• W2070904831 hasConceptScore W2070904831C151730666 @default.
• W2070904831 hasConceptScore W2070904831C167625842 @default.
• W2070904831 hasConceptScore W2070904831C178790620 @default.
• W2070904831 hasConceptScore W2070904831C185592680 @default.
• W2070904831 hasConceptScore W2070904831C186268636 @default.
• W2070904831 hasConceptScore W2070904831C197336794 @default.
• W2070904831 hasConceptScore W2070904831C202751555 @default.
• W2070904831 hasConceptScore W2070904831C2776471321 @default.
• W2070904831 hasConceptScore W2070904831C2776694085 @default.
• W2070904831 hasConceptScore W2070904831C2779281246 @default.
• W2070904831 hasConceptScore W2070904831C2779343474 @default.
• W2070904831 hasConceptScore W2070904831C2779820397 @default.
• W2070904831 hasConceptScore W2070904831C2781303535 @default.
• W2070904831 hasConceptScore W2070904831C33923547 @default.
• W2070904831 hasConceptScore W2070904831C502942594 @default.
• W2070904831 hasConceptScore W2070904831C54355233 @default.
• W2070904831 hasConceptScore W2070904831C55493867 @default.
• W2070904831 hasConceptScore W2070904831C81885089 @default.
• W2070904831 hasConceptScore W2070904831C86803240 @default.
• W2070904831 hasIssue "48" @default.
• W2070904831 hasLocation W20709048311 @default.
• W2070904831 hasLocation W20709048312 @default.
• W2070904831 hasOpenAccess W2070904831 @default.

• next