FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070908417> ?p ?o ?g. }

• W2070908417 endingPage "58" @default.
• W2070908417 startingPage "52" @default.
• W2070908417 abstract "Electrical stimulation of the dorsal periaqueductal gray (dPAG) in rats generates defensive responses that are characterized by freezing and escape behaviors, followed by post-stimulation freezing that resembles symptoms of panic attacks. dPAG post-stimulation freezing involves the processing of ascending aversive information to prosencephalic centers, including the amygdala, which allows the animal to evaluate the consequences of stressful situations. The basolateral nucleus of the amygdala (BLA) is thought to act as a filter for innate and learned aversive information that is transmitted to higher structures. The central (CeA) and medial (MeA) nuclei of the amygdala constitute an output for the expression of fear reactions through projections to limbic and brainstem regions. Neurokinin (NK) receptors are abundant in the CeA, MeA, and BLA, but their role in the expression of defensive responses and processing of aversive information that is evoked by electrical stimulation of the dPAG is still unclear. In the present study, we examined the role of NK1 receptors in these amygdala nuclei in the expression of defensive responses induced by electrical stimulation of the dPAG in rats and fear memory of this aversive stimulation. Rats were implanted with an electrode into the dPAG for electrical stimulation and one cannula in the CeA, MeA, or BLA for injections of vehicle (phosphate-buffered saline) or the NK1 receptor antagonist spantide (SPA; 100 pmol/0.2 μl). Injections of SPA into the CeA but not BLA or MeA reduced the duration of post-stimulation freezing evoked by electrical stimulation of the dPAG, without changing the aversive thresholds of freezing or escape. Twenty-four hours later, exploratory behavior was evaluated in the elevated plus maze test (EPM) in the CeA group of rats. Electrical stimulation of the dPAG rats that received vehicle exhibited higher aversion to the open arms of the EPM than sham rats that did not receive any dPAG stimulation. SPA injections into the CeA prevented the proaversive effects of electrical stimulation of the dPAG assessed in the EPM 24 h later. The present results suggest that neurokininergic modulation via NK1 receptors in the CeA but not BLA or MeA is involved in the processing of aversive information derived from dPAG stimulation. The long-lasting consequences of electrical stimulation of the dPAG may be prevented by NK1 receptor antagonism in the CeA." @default.
• W2070908417 created "2016-06-24" @default.
• W2070908417 creator A5003205039 @default.
• W2070908417 creator A5078885951 @default.
• W2070908417 creator A5079186718 @default.
• W2070908417 date "2015-05-01" @default.
• W2070908417 modified "2023-10-16" @default.
• W2070908417 title "Dorsal periaqueductal gray post-stimulation freezing is counteracted by neurokinin-1 receptor antagonism in the central nucleus of the amygdala in rats" @default.
• W2070908417 cites W1964250712 @default.
• W2070908417 cites W1965591468 @default.
• W2070908417 cites W1969801239 @default.
• W2070908417 cites W1977786504 @default.
• W2070908417 cites W1978080244 @default.
• W2070908417 cites W1978664632 @default.
• W2070908417 cites W1978713404 @default.
• W2070908417 cites W1985068557 @default.
• W2070908417 cites W1989364630 @default.
• W2070908417 cites W1993230172 @default.
• W2070908417 cites W1994389924 @default.
• W2070908417 cites W1998335703 @default.
• W2070908417 cites W2000728228 @default.
• W2070908417 cites W2001883823 @default.
• W2070908417 cites W2002583606 @default.
• W2070908417 cites W2003991837 @default.
• W2070908417 cites W2008904303 @default.
• W2070908417 cites W2019954639 @default.
• W2070908417 cites W2023087007 @default.
• W2070908417 cites W2023497711 @default.
• W2070908417 cites W2028481539 @default.
• W2070908417 cites W2029729547 @default.
• W2070908417 cites W2031849235 @default.
• W2070908417 cites W2037024587 @default.
• W2070908417 cites W2041561931 @default.
• W2070908417 cites W2042520607 @default.
• W2070908417 cites W2044783397 @default.
• W2070908417 cites W2047096153 @default.
• W2070908417 cites W2050254490 @default.
• W2070908417 cites W2053887572 @default.
• W2070908417 cites W2055055749 @default.
• W2070908417 cites W2056093113 @default.
• W2070908417 cites W2057020248 @default.
• W2070908417 cites W2070623386 @default.
• W2070908417 cites W2072598103 @default.
• W2070908417 cites W2075312117 @default.
• W2070908417 cites W2077196351 @default.
• W2070908417 cites W2082091099 @default.
• W2070908417 cites W2082445010 @default.
• W2070908417 cites W2084518983 @default.
• W2070908417 cites W2092127369 @default.
• W2070908417 cites W2093670138 @default.
• W2070908417 cites W2095123857 @default.
• W2070908417 cites W2103725146 @default.
• W2070908417 cites W2113281603 @default.
• W2070908417 cites W2117315687 @default.
• W2070908417 cites W2120275472 @default.
• W2070908417 cites W2124632438 @default.
• W2070908417 cites W2146098523 @default.
• W2070908417 cites W2150168513 @default.
• W2070908417 cites W2159450883 @default.
• W2070908417 cites W2168660234 @default.
• W2070908417 cites W2401253483 @default.
• W2070908417 cites W4232573973 @default.
• W2070908417 doi "https://doi.org/10.1016/j.nlm.2015.04.001" @default.
• W2070908417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25883049" @default.
• W2070908417 hasPublicationYear "2015" @default.
• W2070908417 type Work @default.
• W2070908417 sameAs 2070908417 @default.
• W2070908417 citedByCount "11" @default.
• W2070908417 countsByYear W20709084172016 @default.
• W2070908417 countsByYear W20709084172017 @default.
• W2070908417 countsByYear W20709084172018 @default.
• W2070908417 countsByYear W20709084172019 @default.
• W2070908417 countsByYear W20709084172020 @default.
• W2070908417 countsByYear W20709084172021 @default.
• W2070908417 countsByYear W20709084172022 @default.
• W2070908417 crossrefType "journal-article" @default.
• W2070908417 hasAuthorship W2070908417A5003205039 @default.
• W2070908417 hasAuthorship W2070908417A5078885951 @default.
• W2070908417 hasAuthorship W2070908417A5079186718 @default.
• W2070908417 hasBestOaLocation W20709084171 @default.
• W2070908417 hasConcept C15744967 @default.
• W2070908417 hasConcept C16837860 @default.
• W2070908417 hasConcept C169760540 @default.
• W2070908417 hasConcept C177825189 @default.
• W2070908417 hasConcept C185592680 @default.
• W2070908417 hasConcept C24998067 @default.
• W2070908417 hasConcept C2777426569 @default.
• W2070908417 hasConcept C2779144063 @default.
• W2070908417 hasConcept C2780451725 @default.
• W2070908417 hasConcept C2781069035 @default.
• W2070908417 hasConcept C2781069985 @default.
• W2070908417 hasConcept C2985799443 @default.
• W2070908417 hasConcept C529278444 @default.
• W2070908417 hasConcept C552161191 @default.
• W2070908417 hasConceptScore W2070908417C15744967 @default.
• W2070908417 hasConceptScore W2070908417C16837860 @default.
• W2070908417 hasConceptScore W2070908417C169760540 @default.
• W2070908417 hasConceptScore W2070908417C177825189 @default.

• next