FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070912312> ?p ?o ?g. }

• W2070912312 endingPage "28" @default.
• W2070912312 startingPage "21" @default.
• W2070912312 abstract "Objectives To assess the efficacy and safety of istradefylline as an adjunct to levodopa in patients with Parkinson's Disease (PD). Methods In this study, we searched the Cochrane Library, MEDLINE, Embase, China Academic Journal Full-text Database (CNKI), China Biomedical Literature Database (CBM), Chinese Scientific Journals Database (VIP), and Wanfang Database. The quality of included studies was strictly evaluated. Data analyses were performed by the Cochrane Collaboration's RevMan5.0 software. Results Five randomized controlled trials (RCTs) were included. The result showed a significant reduction of the awake time per day spent in the OFF state and improvement of the Unified Parkinson's Disease Rating Scale (UPDRS) Part III in the ON state when receiving istradefylline compared with patients receiving placebo. There was no significant difference between the istradefylline 20 mg and the istradefylline 40 mg groups in the UPDRS Part III in the ON state (WMD=1.27, 95% CI [−0.40, 2.95]). The results showed significant differences in dyskinesia (RR=1.63, 95% CI [1.16, 2.29]) compared to istradefylline 40 mg with placebo. There was no significant statistical difference with regard to other adverse events. Conclusions The present study showed that istradefylline is safe and effective as an adjunct to levodopa in patients with PD. Future large-scale, higher-quality, long-treatment, and placebo-controlled trials are needed." @default.
• W2070912312 created "2016-06-24" @default.
• W2070912312 creator A5005129835 @default.
• W2070912312 creator A5028169488 @default.
• W2070912312 creator A5047433798 @default.
• W2070912312 creator A5065545649 @default.
• W2070912312 creator A5088057218 @default.
• W2070912312 date "2013-01-01" @default.
• W2070912312 modified "2023-09-26" @default.
• W2070912312 title "Istradefylline, an adenosine A2A receptor antagonist, for patients with Parkinson's Disease: A meta-analysis" @default.
• W2070912312 cites W1561072761 @default.
• W2070912312 cites W1755157204 @default.
• W2070912312 cites W1980384054 @default.
• W2070912312 cites W1986436768 @default.
• W2070912312 cites W1990269363 @default.
• W2070912312 cites W2014175065 @default.
• W2070912312 cites W2028129201 @default.
• W2070912312 cites W2030108063 @default.
• W2070912312 cites W2030257205 @default.
• W2070912312 cites W2037199903 @default.
• W2070912312 cites W2056145524 @default.
• W2070912312 cites W2059395745 @default.
• W2070912312 cites W2064996887 @default.
• W2070912312 cites W2073399017 @default.
• W2070912312 cites W2088277236 @default.
• W2070912312 cites W2115222037 @default.
• W2070912312 cites W2115639304 @default.
• W2070912312 cites W2131371182 @default.
• W2070912312 cites W2146659986 @default.
• W2070912312 cites W2411729407 @default.
• W2070912312 cites W4376848489 @default.
• W2070912312 doi "https://doi.org/10.1016/j.jns.2012.08.030" @default.
• W2070912312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23085003" @default.
• W2070912312 hasPublicationYear "2013" @default.
• W2070912312 type Work @default.
• W2070912312 sameAs 2070912312 @default.
• W2070912312 citedByCount "40" @default.
• W2070912312 countsByYear W20709123122014 @default.
• W2070912312 countsByYear W20709123122015 @default.
• W2070912312 countsByYear W20709123122016 @default.
• W2070912312 countsByYear W20709123122017 @default.
• W2070912312 countsByYear W20709123122018 @default.
• W2070912312 countsByYear W20709123122019 @default.
• W2070912312 countsByYear W20709123122020 @default.
• W2070912312 countsByYear W20709123122021 @default.
• W2070912312 countsByYear W20709123122022 @default.
• W2070912312 crossrefType "journal-article" @default.
• W2070912312 hasAuthorship W2070912312A5005129835 @default.
• W2070912312 hasAuthorship W2070912312A5028169488 @default.
• W2070912312 hasAuthorship W2070912312A5047433798 @default.
• W2070912312 hasAuthorship W2070912312A5065545649 @default.
• W2070912312 hasAuthorship W2070912312A5088057218 @default.
• W2070912312 hasConcept C126322002 @default.
• W2070912312 hasConcept C142724271 @default.
• W2070912312 hasConcept C168563851 @default.
• W2070912312 hasConcept C17744445 @default.
• W2070912312 hasConcept C1862650 @default.
• W2070912312 hasConcept C197934379 @default.
• W2070912312 hasConcept C199539241 @default.
• W2070912312 hasConcept C204787440 @default.
• W2070912312 hasConcept C27081682 @default.
• W2070912312 hasConcept C2776478404 @default.
• W2070912312 hasConcept C2779134260 @default.
• W2070912312 hasConcept C2779473830 @default.
• W2070912312 hasConcept C2779734285 @default.
• W2070912312 hasConcept C2780304432 @default.
• W2070912312 hasConcept C2780405171 @default.
• W2070912312 hasConcept C42219234 @default.
• W2070912312 hasConcept C71924100 @default.
• W2070912312 hasConcept C95190672 @default.
• W2070912312 hasConceptScore W2070912312C126322002 @default.
• W2070912312 hasConceptScore W2070912312C142724271 @default.
• W2070912312 hasConceptScore W2070912312C168563851 @default.
• W2070912312 hasConceptScore W2070912312C17744445 @default.
• W2070912312 hasConceptScore W2070912312C1862650 @default.
• W2070912312 hasConceptScore W2070912312C197934379 @default.
• W2070912312 hasConceptScore W2070912312C199539241 @default.
• W2070912312 hasConceptScore W2070912312C204787440 @default.
• W2070912312 hasConceptScore W2070912312C27081682 @default.
• W2070912312 hasConceptScore W2070912312C2776478404 @default.
• W2070912312 hasConceptScore W2070912312C2779134260 @default.
• W2070912312 hasConceptScore W2070912312C2779473830 @default.
• W2070912312 hasConceptScore W2070912312C2779734285 @default.
• W2070912312 hasConceptScore W2070912312C2780304432 @default.
• W2070912312 hasConceptScore W2070912312C2780405171 @default.
• W2070912312 hasConceptScore W2070912312C42219234 @default.
• W2070912312 hasConceptScore W2070912312C71924100 @default.
• W2070912312 hasConceptScore W2070912312C95190672 @default.
• W2070912312 hasIssue "1-2" @default.
• W2070912312 hasLocation W20709123121 @default.
• W2070912312 hasLocation W20709123122 @default.
• W2070912312 hasOpenAccess W2070912312 @default.
• W2070912312 hasPrimaryLocation W20709123121 @default.
• W2070912312 hasRelatedWork W1967911880 @default.
• W2070912312 hasRelatedWork W2114297254 @default.
• W2070912312 hasRelatedWork W2374685850 @default.
• W2070912312 hasRelatedWork W2759947093 @default.
• W2070912312 hasRelatedWork W3184425712 @default.

• next