Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070920901> ?p ?o ?g. }
- W2070920901 endingPage "15779" @default.
- W2070920901 startingPage "15770" @default.
- W2070920901 abstract "The rate and timing of information transfer at neuronal synapses are critical for determining synaptic efficacy and higher network function. Both synchronous and asynchronous neurotransmitter release shape the pattern of synaptic influences on a neuron. The PSD-95 family of postsynaptic scaffolding proteins, in addition to organizing postsynaptic components at glutamate synapses, acts transcellularly to regulate synchronous glutamate release. Here we show that PSD-95 family members at nicotinic synapses on chick ciliary ganglion neurons in culture execute multiple functions to enhance transmission. Together, endogenous PSD-95 and SAP102 in the postsynaptic cell appear to regulate transcellularly the synchronous release of transmitter from presynaptic terminals onto the neuron while stabilizing postsynaptic nicotinic receptor clusters under the release sites. Endogenous SAP97, in contrast, has no effect on receptor clusters but acts transcellularly from the postsynaptic cell through N-cadherin to enhance asynchronous release. These separate and parallel regulatory pathways allow postsynaptic scaffold proteins to dictate the pattern of cholinergic input a neuron receives; they also require balancing of PSD-95 protein levels to avoid disruptive competition that can occur through common binding domains." @default.
- W2070920901 created "2016-06-24" @default.
- W2070920901 creator A5001790127 @default.
- W2070920901 creator A5009172234 @default.
- W2070920901 creator A5033256804 @default.
- W2070920901 creator A5053058119 @default.
- W2070920901 date "2009-12-16" @default.
- W2070920901 modified "2023-10-12" @default.
- W2070920901 title "Synchronous and Asynchronous Transmitter Release at Nicotinic Synapses Are Differentially Regulated by Postsynaptic PSD-95 Proteins" @default.
- W2070920901 cites W1487695731 @default.
- W2070920901 cites W1514819185 @default.
- W2070920901 cites W1535258423 @default.
- W2070920901 cites W1587172759 @default.
- W2070920901 cites W1668891956 @default.
- W2070920901 cites W1774348706 @default.
- W2070920901 cites W1895983915 @default.
- W2070920901 cites W1902144670 @default.
- W2070920901 cites W1902548357 @default.
- W2070920901 cites W1934489743 @default.
- W2070920901 cites W1966761076 @default.
- W2070920901 cites W1978224954 @default.
- W2070920901 cites W1980958746 @default.
- W2070920901 cites W1981000354 @default.
- W2070920901 cites W1981286146 @default.
- W2070920901 cites W1981990802 @default.
- W2070920901 cites W1991242249 @default.
- W2070920901 cites W1995184912 @default.
- W2070920901 cites W1995949213 @default.
- W2070920901 cites W1997381540 @default.
- W2070920901 cites W2010152646 @default.
- W2070920901 cites W2010575732 @default.
- W2070920901 cites W2011910037 @default.
- W2070920901 cites W2012981686 @default.
- W2070920901 cites W2014907593 @default.
- W2070920901 cites W2015556634 @default.
- W2070920901 cites W2016493999 @default.
- W2070920901 cites W2017980759 @default.
- W2070920901 cites W2018885303 @default.
- W2070920901 cites W2019766891 @default.
- W2070920901 cites W2019873695 @default.
- W2070920901 cites W2020850910 @default.
- W2070920901 cites W2020852951 @default.
- W2070920901 cites W2022195500 @default.
- W2070920901 cites W2028055687 @default.
- W2070920901 cites W2032531834 @default.
- W2070920901 cites W2037168572 @default.
- W2070920901 cites W2040729638 @default.
- W2070920901 cites W2041477218 @default.
- W2070920901 cites W2046165746 @default.
- W2070920901 cites W2051316680 @default.
- W2070920901 cites W2055374196 @default.
- W2070920901 cites W2058022492 @default.
- W2070920901 cites W2059381606 @default.
- W2070920901 cites W2059480421 @default.
- W2070920901 cites W2062419094 @default.
- W2070920901 cites W2065049421 @default.
- W2070920901 cites W2065158671 @default.
- W2070920901 cites W2067187413 @default.
- W2070920901 cites W2068240232 @default.
- W2070920901 cites W2069314342 @default.
- W2070920901 cites W2078029552 @default.
- W2070920901 cites W2081376704 @default.
- W2070920901 cites W2082411508 @default.
- W2070920901 cites W2087758815 @default.
- W2070920901 cites W2088239473 @default.
- W2070920901 cites W2097424141 @default.
- W2070920901 cites W2102405317 @default.
- W2070920901 cites W2108193936 @default.
- W2070920901 cites W2115460562 @default.
- W2070920901 cites W2118064450 @default.
- W2070920901 cites W2121581566 @default.
- W2070920901 cites W2133219198 @default.
- W2070920901 cites W2146526204 @default.
- W2070920901 cites W2151522879 @default.
- W2070920901 cites W2153657429 @default.
- W2070920901 cites W2154405330 @default.
- W2070920901 cites W2157827370 @default.
- W2070920901 cites W2162918865 @default.
- W2070920901 cites W2162931951 @default.
- W2070920901 cites W2216018617 @default.
- W2070920901 cites W2399196779 @default.
- W2070920901 cites W3109053335 @default.
- W2070920901 doi "https://doi.org/10.1523/jneurosci.4951-09.2009" @default.
- W2070920901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2844112" @default.
- W2070920901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20016093" @default.
- W2070920901 hasPublicationYear "2009" @default.
- W2070920901 type Work @default.
- W2070920901 sameAs 2070920901 @default.
- W2070920901 citedByCount "19" @default.
- W2070920901 countsByYear W20709209012012 @default.
- W2070920901 countsByYear W20709209012013 @default.
- W2070920901 countsByYear W20709209012014 @default.
- W2070920901 countsByYear W20709209012015 @default.
- W2070920901 countsByYear W20709209012016 @default.
- W2070920901 countsByYear W20709209012017 @default.
- W2070920901 countsByYear W20709209012021 @default.
- W2070920901 crossrefType "journal-article" @default.
- W2070920901 hasAuthorship W2070920901A5001790127 @default.