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- W2070927058 abstract "in vitro, Type I receptors have high and equivalent affinity for aldosterone, corticosterone and cortisol : in vivo, physiological mineralocorticoid target tissues (kidney, colon, parotid) are highly aldosterone-selective, in contrast with hippocampus and heart. In the present study we show that the mesenteric vascular arcade is similarly highly aldosterone-selective in vivo, and in vitro shows considerable levels of 1130H steroid dehydrogenase activity, previously postulated as the mechanism whereby glucocorticoids are excluded from physiological mineralocorticoid receptors." @default.
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- W2070927058 date "1989-10-01" @default.
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- W2070927058 title "VASCULAR TYPE I ALDOSTERONE BINDING SITES ARE PHYSIOLOGICAL MINERALOCORTICOID RECEPTORS" @default.
- W2070927058 doi "https://doi.org/10.1210/endo-125-4-2224" @default.
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