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- W2070933218 abstract "In order to investigate the response of breast cancer cells to anticancer drugs as a function of hormone receptors, 69 specimens obtained from the primary tumor of invasive breast cancer patients were cultivated using the human tumor clonogenic assay. Successful growth in vitro (≥ 30 colonies per plate) was obtained in 50 (72.5%) of the 69 viable samples, with a median cloning efficiency of 0.17%. Five drugs (adriamycin, vincristine, 5-fluorouracil, carmustine, methotrexate) were tested for each specimen resulting in 250 drug assays. The overall drug sensitivity was 47.2%. Of these, 5-fluorouracil had the greatest effect in vitro with a sensitivity of 68.0%. There was no significant correlation between hormone receptor status and response to anticancer drugs either overall or for agents analyzed individually. It is concluded that hormone receptors of breast cancer have no predictive value for response to chemotherapy." @default.
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- W2070933218 date "1988-09-01" @default.
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- W2070933218 title "Hormone receptor status and chemosensitivity in breast cancer" @default.
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- W2070933218 doi "https://doi.org/10.1007/bf02997635" @default.
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