Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070934690> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2070934690 abstract "Platelet-activating factor (PAF) is a powerful phospholipid-derived autacoid involved in many physiopathological mechanisms. Many PAF antagonists have been synthesized and evaluated as therapeutic candidates. In a previous report, we have described an electronic pharmacophore of PAF antagonists using the molecular electrostatic potential. In the present study, a molecular lipophilicity potential is used to compare the hydrophobic properties of 49 heterocyclic sp2 nitrogen' highly potent PAF antagonists, belonging to six structurally different series (nine hetrazepines, five pyrrolo[1,2-c]thiazoles, 14 carboxamides, nine dihydropyridines, nine pyridinyl-thiazolidines and three imidazo[4,5-c]pyridines). Their common features consist of three hydrophilic (HYD2, HY14(3)B and HYD3) and two lipophilic zones (LIP3 and LIP4), defining the lipophilic pharmacophore of the antagonists. This pharmacophore is also characterized by several zone-to-zone distances: HYD3-HYD2 = 1.3 +/- 1.0 A, HY3B-HYD2 = 7.8 +/- 1.1, HYD3-HY3B = 5.1 +/- 1.1 A, LIP4-LIP3 = 5.4 +/- 1.1 A, LIP3-HYD2 = 11.3 +/- 1.6 A, LIP3-HY3B = 5.9 +/- 1.0 A, LIP3-HYD3 = 4.3 +/- 0.9 A, LIP4-HYD2 = 14.7 +/- 1.6 A, LIP4-HY3B = 8.1 +/- 1.2 A and LIP4-HYD3 = 3.9 +/- 1.1 A. These results represent a new step in the determination of a global pharmacophore for PAF antagonists." @default.
- W2070934690 created "2016-06-24" @default.
- W2070934690 creator A5003455781 @default.
- W2070934690 creator A5020315874 @default.
- W2070934690 creator A5041382285 @default.
- W2070934690 creator A5069037311 @default.
- W2070934690 date "1997-06-01" @default.
- W2070934690 modified "2023-09-26" @default.
- W2070934690 title "A pharmacophore for high affinity PAF antagonists II. Hydrophobicity study using the molecular lipophilicity potential" @default.
- W2070934690 cites W1570643773 @default.
- W2070934690 cites W1963718414 @default.
- W2070934690 cites W1973560094 @default.
- W2070934690 cites W1975058685 @default.
- W2070934690 cites W1977296279 @default.
- W2070934690 cites W1978316605 @default.
- W2070934690 cites W1980945864 @default.
- W2070934690 cites W1982141201 @default.
- W2070934690 cites W1984776927 @default.
- W2070934690 cites W1985616236 @default.
- W2070934690 cites W1986932919 @default.
- W2070934690 cites W1999998965 @default.
- W2070934690 cites W2003042744 @default.
- W2070934690 cites W2010135053 @default.
- W2070934690 cites W2016397201 @default.
- W2070934690 cites W2020813894 @default.
- W2070934690 cites W2023594621 @default.
- W2070934690 cites W2035834604 @default.
- W2070934690 cites W2043934481 @default.
- W2070934690 cites W2052607605 @default.
- W2070934690 cites W2061048073 @default.
- W2070934690 cites W2065369021 @default.
- W2070934690 cites W2071457411 @default.
- W2070934690 cites W2072290661 @default.
- W2070934690 cites W2072555086 @default.
- W2070934690 cites W2080563827 @default.
- W2070934690 cites W2083158017 @default.
- W2070934690 cites W2084550441 @default.
- W2070934690 cites W2086996725 @default.
- W2070934690 cites W2091371100 @default.
- W2070934690 cites W2091638751 @default.
- W2070934690 cites W2094387561 @default.
- W2070934690 cites W2094591181 @default.
- W2070934690 cites W2133484383 @default.
- W2070934690 cites W2141178517 @default.
- W2070934690 cites W2322728098 @default.
- W2070934690 cites W2951009957 @default.
- W2070934690 cites W2951495846 @default.
- W2070934690 cites W2951541975 @default.
- W2070934690 cites W2952422806 @default.
- W2070934690 cites W4244676158 @default.
- W2070934690 doi "https://doi.org/10.1016/s0929-7855(97)00574-9" @default.
- W2070934690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9172050" @default.
- W2070934690 hasPublicationYear "1997" @default.
- W2070934690 type Work @default.
- W2070934690 sameAs 2070934690 @default.
- W2070934690 citedByCount "2" @default.
- W2070934690 countsByYear W20709346902019 @default.
- W2070934690 crossrefType "journal-article" @default.
- W2070934690 hasAuthorship W2070934690A5003455781 @default.
- W2070934690 hasAuthorship W2070934690A5020315874 @default.
- W2070934690 hasAuthorship W2070934690A5041382285 @default.
- W2070934690 hasAuthorship W2070934690A5069037311 @default.
- W2070934690 hasConcept C126322002 @default.
- W2070934690 hasConcept C178910836 @default.
- W2070934690 hasConcept C185592680 @default.
- W2070934690 hasConcept C201399114 @default.
- W2070934690 hasConcept C21951064 @default.
- W2070934690 hasConcept C2779020240 @default.
- W2070934690 hasConcept C56173144 @default.
- W2070934690 hasConcept C71240020 @default.
- W2070934690 hasConcept C71924100 @default.
- W2070934690 hasConceptScore W2070934690C126322002 @default.
- W2070934690 hasConceptScore W2070934690C178910836 @default.
- W2070934690 hasConceptScore W2070934690C185592680 @default.
- W2070934690 hasConceptScore W2070934690C201399114 @default.
- W2070934690 hasConceptScore W2070934690C21951064 @default.
- W2070934690 hasConceptScore W2070934690C2779020240 @default.
- W2070934690 hasConceptScore W2070934690C56173144 @default.
- W2070934690 hasConceptScore W2070934690C71240020 @default.
- W2070934690 hasConceptScore W2070934690C71924100 @default.
- W2070934690 hasLocation W20709346901 @default.
- W2070934690 hasLocation W20709346902 @default.
- W2070934690 hasOpenAccess W2070934690 @default.
- W2070934690 hasPrimaryLocation W20709346901 @default.
- W2070934690 hasRelatedWork W1985380316 @default.
- W2070934690 hasRelatedWork W2007352684 @default.
- W2070934690 hasRelatedWork W2039562705 @default.
- W2070934690 hasRelatedWork W2070934690 @default.
- W2070934690 hasRelatedWork W2083198657 @default.
- W2070934690 hasRelatedWork W2084550441 @default.
- W2070934690 hasRelatedWork W2084627928 @default.
- W2070934690 hasRelatedWork W2412090276 @default.
- W2070934690 hasRelatedWork W2417650495 @default.
- W2070934690 hasRelatedWork W2990694218 @default.
- W2070934690 isParatext "false" @default.
- W2070934690 isRetracted "false" @default.
- W2070934690 magId "2070934690" @default.
- W2070934690 workType "article" @default.