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- W2070944006 abstract "Peroxidation of blood lipoproteins is regarded as a key event in the development of atherosclerosis. Hence, attenuation of the oxidative modification of lipoproteins by natural and synthetic antioxidants in vivo is considered a possible way of prevention of cardiovascular disorders. The assessment of the susceptibility of lipoproteins to oxidation is commonly based on in vitro oxidation experiments. Monitoring of oxidation provides the kinetic profile characteristic for the given lipoprotein preparation. The kinetic profile of peroxidation is characterized by three major parameters: the lag preceding rapid oxidation, the maximal rate of oxidation (V(max)) and the maximal accumulation of oxidation products (OD(max)). Addition of antioxidants alters this pattern, affecting the kinetic parameters of oxidation. In particular, antioxidants may prolong the lag and/or decrease the V(max) and/or decrease the OD(max). Such specific variation of the set of kinetic parameters may provide important information on the mechanism of the inhibitory action of a given antioxidant (scavenging free radicals, metal-binding or other mechanisms). Numerous natural and synthetic compounds were reported to inhibit oxidation of lipoproteins. Based on the analysis of reported effects and theoretical considerations, we propose a simple protocol that relates the kinetic effects of a given antioxidant to the mechanism of its action." @default.
- W2070944006 created "2016-06-24" @default.
- W2070944006 creator A5035182019 @default.
- W2070944006 creator A5081847618 @default.
- W2070944006 date "2002-07-01" @default.
- W2070944006 modified "2023-09-27" @default.
- W2070944006 title "The mechanism of action of antioxidants against lipoprotein peroxidation, evaluation based on kinetic experiments" @default.
- W2070944006 cites W1124883296 @default.
- W2070944006 cites W1512889873 @default.
- W2070944006 cites W1538731517 @default.
- W2070944006 cites W1563303466 @default.
- W2070944006 cites W1584223459 @default.
- W2070944006 cites W1592637939 @default.
- W2070944006 cites W1631803278 @default.
- W2070944006 cites W1869682857 @default.
- W2070944006 cites W1885703212 @default.
- W2070944006 cites W1890102384 @default.
- W2070944006 cites W1963781173 @default.
- W2070944006 cites W1965095388 @default.
- W2070944006 cites W1965617246 @default.
- W2070944006 cites W1966481028 @default.
- W2070944006 cites W1970185441 @default.
- W2070944006 cites W1970809716 @default.
- W2070944006 cites W1972762870 @default.
- W2070944006 cites W1973145121 @default.
- W2070944006 cites W1976895929 @default.
- W2070944006 cites W1977027049 @default.
- W2070944006 cites W1981098210 @default.
- W2070944006 cites W1981665223 @default.
- W2070944006 cites W1984592542 @default.
- W2070944006 cites W1990750844 @default.
- W2070944006 cites W1997745709 @default.
- W2070944006 cites W2002763248 @default.
- W2070944006 cites W2005919811 @default.
- W2070944006 cites W2006384611 @default.
- W2070944006 cites W2011502676 @default.
- W2070944006 cites W2012771428 @default.
- W2070944006 cites W2015341133 @default.
- W2070944006 cites W2015887844 @default.
- W2070944006 cites W2018309586 @default.
- W2070944006 cites W2019017347 @default.
- W2070944006 cites W2021115743 @default.
- W2070944006 cites W2021378329 @default.
- W2070944006 cites W2022384805 @default.
- W2070944006 cites W2024888328 @default.
- W2070944006 cites W2025679035 @default.
- W2070944006 cites W2029825717 @default.
- W2070944006 cites W2031221948 @default.
- W2070944006 cites W2033275550 @default.
- W2070944006 cites W2038167180 @default.
- W2070944006 cites W2041394247 @default.
- W2070944006 cites W2044742166 @default.
- W2070944006 cites W2048039428 @default.
- W2070944006 cites W2048933009 @default.
- W2070944006 cites W2050025844 @default.
- W2070944006 cites W2050601245 @default.
- W2070944006 cites W2051110115 @default.
- W2070944006 cites W2052840029 @default.
- W2070944006 cites W2056658522 @default.
- W2070944006 cites W2056735508 @default.
- W2070944006 cites W2057872261 @default.
- W2070944006 cites W2060360501 @default.
- W2070944006 cites W2060481860 @default.
- W2070944006 cites W2060915587 @default.
- W2070944006 cites W2061242359 @default.
- W2070944006 cites W2065017757 @default.
- W2070944006 cites W2066920207 @default.
- W2070944006 cites W2071258150 @default.
- W2070944006 cites W2073324936 @default.
- W2070944006 cites W2073464812 @default.
- W2070944006 cites W2073895463 @default.
- W2070944006 cites W2080887633 @default.
- W2070944006 cites W2082092019 @default.
- W2070944006 cites W2083259778 @default.
- W2070944006 cites W2087576623 @default.
- W2070944006 cites W2090217818 @default.
- W2070944006 cites W2093709215 @default.
- W2070944006 cites W2095480274 @default.
- W2070944006 cites W2098646953 @default.
- W2070944006 cites W2101878571 @default.
- W2070944006 cites W2105440647 @default.
- W2070944006 cites W2108284453 @default.
- W2070944006 cites W2110457085 @default.
- W2070944006 cites W2113209574 @default.
- W2070944006 cites W2116630728 @default.
- W2070944006 cites W2126586941 @default.
- W2070944006 cites W2131017492 @default.
- W2070944006 cites W2139755134 @default.
- W2070944006 cites W2144522249 @default.
- W2070944006 cites W2148050730 @default.
- W2070944006 cites W2150545098 @default.
- W2070944006 cites W2170189255 @default.
- W2070944006 cites W2170748270 @default.
- W2070944006 cites W2170967215 @default.
- W2070944006 cites W2181859739 @default.
- W2070944006 cites W2182127426 @default.
- W2070944006 cites W2212323528 @default.
- W2070944006 cites W2260810937 @default.