FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070944220> ?p ?o ?g. }

• W2070944220 abstract "Background— Ranolazine (Ran), an antianginal agent, inhibits late Na + current. The purpose of this study was to determine whether there was an added benefit of adding Ran to cardioplegia (CP) in a model of global ischemia/reperfusion. Methods and Results— Isolated rat hearts were Langendorff-perfused and exposed to 40-minute normothermic, cardioplegic global ischemia and 30 minutes of reperfusion. Before ischemia and during reperfusion, hearts were treated with no drug (control) or with the late Na + current inhibitors Ran (5 μmol/L) or tetrodotoxin (1 μmol/L). Ischemic cardioplegic arrest led to an increase of left ventricular end-diastolic pressure (LVEDP) by ≥20 mm Hg (ie, cardiac contracture). Ten out of 11 hearts treated with CP alone developed contracture, whereas 6 out of 11 hearts treated with CP plus Ran developed contracture. Ran added to CP reduced LVEDP at the end of ischemia from 41±5 mm Hg in CP alone to 26±3 mm Hg in CP plus Ran ( P =0.024). Area under the curve for LVEDP during the entire ischemic period was also smaller in CP plus Ran versus CP alone. The percent increase (from baseline) of LVEDP measured at the end of 30-minute reperfusion was smaller for CP plus Ran (66±18%) versus CP alone (287±90%; P =0.035). The area under the curve for LVEDP during reperfusion was smaller in CP plus Ran versus CP alone. Tetrodotoxin (1 μmol/L) also reduced cardiac contracture during ischemia/reperfusion, compared to CP alone. Conclusions— Our results suggest that Ran may have therapeutic potential as an adjunct to CP and further support a protective role of Na + current inhibition during ischemia/reperfusion." @default.
• W2070944220 created "2016-06-24" @default.
• W2070944220 creator A5015839705 @default.
• W2070944220 creator A5016568391 @default.
• W2070944220 creator A5027473085 @default.
• W2070944220 creator A5031350316 @default.
• W2070944220 creator A5034048518 @default.
• W2070944220 creator A5043772939 @default.
• W2070944220 creator A5048102172 @default.
• W2070944220 creator A5056673833 @default.
• W2070944220 date "2009-09-15" @default.
• W2070944220 modified "2023-09-27" @default.
• W2070944220 title "Ranolazine as a Cardioplegia Additive Improves Recovery of Diastolic Function in Isolated Rat Hearts" @default.
• W2070944220 cites W102475271 @default.
• W2070944220 cites W1965097623 @default.
• W2070944220 cites W1983986458 @default.
• W2070944220 cites W1989441641 @default.
• W2070944220 cites W2003084475 @default.
• W2070944220 cites W2004643053 @default.
• W2070944220 cites W2018459776 @default.
• W2070944220 cites W2037534562 @default.
• W2070944220 cites W2045377209 @default.
• W2070944220 cites W2049390983 @default.
• W2070944220 cites W2065116798 @default.
• W2070944220 cites W2073668622 @default.
• W2070944220 cites W2085802769 @default.
• W2070944220 cites W2132386089 @default.
• W2070944220 cites W2142178276 @default.
• W2070944220 cites W2148346557 @default.
• W2070944220 cites W2167225420 @default.
• W2070944220 cites W2406809967 @default.
• W2070944220 cites W4298051975 @default.
• W2070944220 cites W4361805466 @default.
• W2070944220 doi "https://doi.org/10.1161/circulationaha.108.844167" @default.
• W2070944220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19752362" @default.
• W2070944220 hasPublicationYear "2009" @default.
• W2070944220 type Work @default.
• W2070944220 sameAs 2070944220 @default.
• W2070944220 citedByCount "35" @default.
• W2070944220 countsByYear W20709442202012 @default.
• W2070944220 countsByYear W20709442202013 @default.
• W2070944220 countsByYear W20709442202014 @default.
• W2070944220 countsByYear W20709442202015 @default.
• W2070944220 countsByYear W20709442202016 @default.
• W2070944220 countsByYear W20709442202017 @default.
• W2070944220 countsByYear W20709442202020 @default.
• W2070944220 countsByYear W20709442202021 @default.
• W2070944220 crossrefType "journal-article" @default.
• W2070944220 hasAuthorship W2070944220A5015839705 @default.
• W2070944220 hasAuthorship W2070944220A5016568391 @default.
• W2070944220 hasAuthorship W2070944220A5027473085 @default.
• W2070944220 hasAuthorship W2070944220A5031350316 @default.
• W2070944220 hasAuthorship W2070944220A5034048518 @default.
• W2070944220 hasAuthorship W2070944220A5043772939 @default.
• W2070944220 hasAuthorship W2070944220A5048102172 @default.
• W2070944220 hasAuthorship W2070944220A5056673833 @default.
• W2070944220 hasBestOaLocation W20709442201 @default.
• W2070944220 hasConcept C126322002 @default.
• W2070944220 hasConcept C141071460 @default.
• W2070944220 hasConcept C164705383 @default.
• W2070944220 hasConcept C178853913 @default.
• W2070944220 hasConcept C2776937108 @default.
• W2070944220 hasConcept C2779177932 @default.
• W2070944220 hasConcept C42219234 @default.
• W2070944220 hasConcept C48277249 @default.
• W2070944220 hasConcept C541997718 @default.
• W2070944220 hasConcept C57900726 @default.
• W2070944220 hasConcept C71924100 @default.
• W2070944220 hasConcept C84393581 @default.
• W2070944220 hasConceptScore W2070944220C126322002 @default.
• W2070944220 hasConceptScore W2070944220C141071460 @default.
• W2070944220 hasConceptScore W2070944220C164705383 @default.
• W2070944220 hasConceptScore W2070944220C178853913 @default.
• W2070944220 hasConceptScore W2070944220C2776937108 @default.
• W2070944220 hasConceptScore W2070944220C2779177932 @default.
• W2070944220 hasConceptScore W2070944220C42219234 @default.
• W2070944220 hasConceptScore W2070944220C48277249 @default.
• W2070944220 hasConceptScore W2070944220C541997718 @default.
• W2070944220 hasConceptScore W2070944220C57900726 @default.
• W2070944220 hasConceptScore W2070944220C71924100 @default.
• W2070944220 hasConceptScore W2070944220C84393581 @default.
• W2070944220 hasIssue "11_suppl_1" @default.
• W2070944220 hasLocation W20709442201 @default.
• W2070944220 hasLocation W20709442202 @default.
• W2070944220 hasOpenAccess W2070944220 @default.
• W2070944220 hasPrimaryLocation W20709442201 @default.
• W2070944220 hasRelatedWork W1797286014 @default.
• W2070944220 hasRelatedWork W2026169786 @default.
• W2070944220 hasRelatedWork W2070944220 @default.
• W2070944220 hasRelatedWork W2096904442 @default.
• W2070944220 hasRelatedWork W2101034561 @default.
• W2070944220 hasRelatedWork W2136380229 @default.
• W2070944220 hasRelatedWork W2333393922 @default.
• W2070944220 hasRelatedWork W2375561537 @default.
• W2070944220 hasRelatedWork W3002540872 @default.
• W2070944220 hasRelatedWork W3182823005 @default.
• W2070944220 hasVolume "120" @default.
• W2070944220 isParatext "false" @default.
• W2070944220 isRetracted "false" @default.
• W2070944220 magId "2070944220" @default.

• next