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- W2070953417 abstract "Selenium is an essential trace element in mammals and is thought to play a chemopreventive role in human cancer, possibly by inducing tumor cell apoptosis. Mitochondria play a pivotal role in the induction of apoptosis in many cell types. The effects of selenite on mitochondrial function were therefore investigated. Selenite induced the oxidation and cross-linking of protein thiol groups, mitochondrial permeability transition (MPT), a decrease in the mitochondrial membrane potential, and the release of cytochrome c in mitochondria isolated from rat liver. Induction of the MPT by selenite was prevented by cyclosporin A, EGTA, or N-ethylmaleimide. These results thus indicate that selenite induces the MPT as a result of direct modification of protein thiol groups, resulting in the release of cytochrome c and a loss of mitochondrial membrane potential." @default.
- W2070953417 created "2016-06-24" @default.
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- W2070953417 date "2002-06-01" @default.
- W2070953417 modified "2023-10-12" @default.
- W2070953417 title "Dysfunction of rat liver mitochondria by selenite: induction of mitochondrial permeability transition through thiol-oxidation" @default.
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- W2070953417 doi "https://doi.org/10.1016/s0006-291x(02)00612-5" @default.
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