Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070967631> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2070967631 endingPage "1061" @default.
- W2070967631 startingPage "1061" @default.
- W2070967631 abstract "Although chronic liver dysfunction in β Thalassaemia major has been associated with transfusion induced iron overload. Chronic Hepatitis B virus (HBV) infection has also recently been implicated. We, therefore, studied 16 children (8 male, 8 female) aged 1-14 years, to assess the influence of iron overload measured by serum ferritin and the volume of transfused blood, and the presence of markers of HBV infection (HBs Ag, HBc Ab, HBs Ab) on liver dysfunction. Thirteen children had elevated serum transaminases; 6 of these had received > 10D units of blood and had had serum ferritin levels of > 6,000mcg/L. All 16 received chelation therapy with a fall in serum ferritin levels from a maximum of 1280-13, 900mcg/L to a minimum of 370-5, 450mcg/L. Concommitant improvement in liver function occured in 10. Although 11 patients had visited HBV endemic areas and 6 had been transfused there, only 2 developed markers of HBV infection. Both had clinical, biochemical and serological evidence of acute HBV infection; they had abnormal liver function prior to the HBV infection, and transaminases returned to these levels after the acute HBV infection. Thus in children, iron overload rather than HBV infection is the major cause of chronic liver dysfunction. However, active immunisation against HBV is necessary to protect these children who commonly receive transfusion whilst in endemic areas." @default.
- W2070967631 created "2016-06-24" @default.
- W2070967631 creator A5069431649 @default.
- W2070967631 date "1986-10-01" @default.
- W2070967631 modified "2023-10-17" @default.
- W2070967631 title "166 THE RELATIONSHIP BETWEEN DISTURBED LIVER FUNCTION, IRON AND MARKERS OF HEPATITIS B UIRUS INFECTION IN BRITISH CHILDREN WITH BETA THALASSAEPIIA" @default.
- W2070967631 doi "https://doi.org/10.1203/00006450-198610000-00221" @default.
- W2070967631 hasPublicationYear "1986" @default.
- W2070967631 type Work @default.
- W2070967631 sameAs 2070967631 @default.
- W2070967631 citedByCount "0" @default.
- W2070967631 crossrefType "journal-article" @default.
- W2070967631 hasAuthorship W2070967631A5069431649 @default.
- W2070967631 hasBestOaLocation W20709676311 @default.
- W2070967631 hasConcept C126322002 @default.
- W2070967631 hasConcept C159654299 @default.
- W2070967631 hasConcept C203014093 @default.
- W2070967631 hasConcept C2522874641 @default.
- W2070967631 hasConcept C2777382497 @default.
- W2070967631 hasConcept C2778319317 @default.
- W2070967631 hasConcept C2780593183 @default.
- W2070967631 hasConcept C2992208098 @default.
- W2070967631 hasConcept C3020491458 @default.
- W2070967631 hasConcept C45189115 @default.
- W2070967631 hasConcept C512861765 @default.
- W2070967631 hasConcept C71924100 @default.
- W2070967631 hasConcept C90924648 @default.
- W2070967631 hasConceptScore W2070967631C126322002 @default.
- W2070967631 hasConceptScore W2070967631C159654299 @default.
- W2070967631 hasConceptScore W2070967631C203014093 @default.
- W2070967631 hasConceptScore W2070967631C2522874641 @default.
- W2070967631 hasConceptScore W2070967631C2777382497 @default.
- W2070967631 hasConceptScore W2070967631C2778319317 @default.
- W2070967631 hasConceptScore W2070967631C2780593183 @default.
- W2070967631 hasConceptScore W2070967631C2992208098 @default.
- W2070967631 hasConceptScore W2070967631C3020491458 @default.
- W2070967631 hasConceptScore W2070967631C45189115 @default.
- W2070967631 hasConceptScore W2070967631C512861765 @default.
- W2070967631 hasConceptScore W2070967631C71924100 @default.
- W2070967631 hasConceptScore W2070967631C90924648 @default.
- W2070967631 hasIssue "10" @default.
- W2070967631 hasLocation W20709676311 @default.
- W2070967631 hasOpenAccess W2070967631 @default.
- W2070967631 hasPrimaryLocation W20709676311 @default.
- W2070967631 hasRelatedWork W2363002749 @default.
- W2070967631 hasRelatedWork W2370533593 @default.
- W2070967631 hasRelatedWork W2372856827 @default.
- W2070967631 hasRelatedWork W2374408774 @default.
- W2070967631 hasRelatedWork W2377047068 @default.
- W2070967631 hasRelatedWork W2386823281 @default.
- W2070967631 hasRelatedWork W2392949109 @default.
- W2070967631 hasRelatedWork W2439419862 @default.
- W2070967631 hasRelatedWork W3031221734 @default.
- W2070967631 hasRelatedWork W4315798409 @default.
- W2070967631 hasVolume "20" @default.
- W2070967631 isParatext "false" @default.
- W2070967631 isRetracted "false" @default.
- W2070967631 magId "2070967631" @default.
- W2070967631 workType "article" @default.