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• W2070968914 abstract "In this study, we report the DNA interaction and cytotoxicity of four dibenzoxanthene compounds 1–4. The binding behaviors of these compounds to calf thymus DNA were studied by absorption titration, viscosity measurements. The DNA binding constants of compounds 1, 2, 3, and 4 are 5.05×104, 2.13×103, 5.10×104, and 3.03×103 M−1, respectively. The lipophilicity of the compounds was determined by the shake flask method. The cytotoxicity of these compounds has been assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. These compounds exhibit high activity against BEL-7402, Hela, MG-63, and SKBR-3 cells. The cell cycle arrest was analyzed by flow cytometry. These compounds inhibit S phase of BEL-7402 and SKBR-3 cells. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (•OH). Four compounds of this family bind DNA, are cytotoxic in an in vitro assay of mitochondrial potential, show antioxidant activity, and cause damage during S phase in cell lines." @default.
• W2070968914 created "2016-06-24" @default.
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• W2070968914 date "2012-09-01" @default.
• W2070968914 modified "2023-10-16" @default.
• W2070968914 title "Cytotoxicity, Cell Cycle Arrest, Antioxidant Activity and Interaction of Dibenzoxanthenes Derivatives with DNA" @default.
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• W2070968914 doi "https://doi.org/10.1089/dna.2012.1726" @default.
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