Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070974158> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2070974158 endingPage "60" @default.
- W2070974158 startingPage "49" @default.
- W2070974158 abstract "Evidence is presented to show that small unilamellar phosphatidylcholine vesicles with a diameter of approx. 20 nm are osmotically sensitive. Such vesicles respond to osmotic pressure by swelling or shrinking depending on the direction of the applied salt gradient. This is true for small unilamellar vesicles of egg phosphatidylcholine and dimyristoylphosphatidylcholine below and above their crystal-to-liquid crystal transition temperature. At the transition temperature the vesicles are osmotically insensitive due to the increased bilayer permeability resulting in rapid dissipation of salt gradients. Positive salt gradients produce shrinking and collapse of spherical phospholipid vesicles to disks. Shrinking of vesicles is associated with H2O and solute efflux, but only limited solute influx. Clustering of lipid molecules in the bilayers of the resulting disks can be detected by EPR spin labeling. Negative salt gradients produce swelling of vesicles which is associated with H2O and solute influx. Our experiments are consistent with an osmotically perturbed bilayer. In the presence of osmotic gradients the influx and efflux of H2O is coupled with the movement of ions and small molecules which in the absence of salt gradients or osmotic stress cannot pass the phospholipid bilayer. However, during osmotically induced shrinking and swelling of SUV the integrity of the phospholipid bilayer is maintained to the extent that vesicles do not break, and therefore equilibration between external medium and vesicle cavity does not take place." @default.
- W2070974158 created "2016-06-24" @default.
- W2070974158 creator A5017480693 @default.
- W2070974158 creator A5031891640 @default.
- W2070974158 creator A5088267211 @default.
- W2070974158 date "1993-10-01" @default.
- W2070974158 modified "2023-09-23" @default.
- W2070974158 title "Thermodynamic stability and osmotic sensitivity of small unilamellar phosphatidylcholine vesicles" @default.
- W2070974158 cites W154334681 @default.
- W2070974158 cites W1982161696 @default.
- W2070974158 cites W1984129626 @default.
- W2070974158 cites W1984569897 @default.
- W2070974158 cites W1997854874 @default.
- W2070974158 cites W2006648837 @default.
- W2070974158 cites W2014033613 @default.
- W2070974158 cites W2018290999 @default.
- W2070974158 cites W2018410651 @default.
- W2070974158 cites W2024437164 @default.
- W2070974158 cites W2030324228 @default.
- W2070974158 cites W2038225831 @default.
- W2070974158 cites W2043913223 @default.
- W2070974158 cites W2048679742 @default.
- W2070974158 cites W2055102358 @default.
- W2070974158 cites W2055323057 @default.
- W2070974158 cites W2074839015 @default.
- W2070974158 cites W2085851961 @default.
- W2070974158 cites W2105341627 @default.
- W2070974158 doi "https://doi.org/10.1016/0005-2736(93)90230-w" @default.
- W2070974158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8399305" @default.
- W2070974158 hasPublicationYear "1993" @default.
- W2070974158 type Work @default.
- W2070974158 sameAs 2070974158 @default.
- W2070974158 citedByCount "21" @default.
- W2070974158 countsByYear W20709741582013 @default.
- W2070974158 countsByYear W20709741582016 @default.
- W2070974158 countsByYear W20709741582017 @default.
- W2070974158 countsByYear W20709741582021 @default.
- W2070974158 countsByYear W20709741582022 @default.
- W2070974158 crossrefType "journal-article" @default.
- W2070974158 hasAuthorship W2070974158A5017480693 @default.
- W2070974158 hasAuthorship W2070974158A5031891640 @default.
- W2070974158 hasAuthorship W2070974158A5088267211 @default.
- W2070974158 hasConcept C12554922 @default.
- W2070974158 hasConcept C130316041 @default.
- W2070974158 hasConcept C185592680 @default.
- W2070974158 hasConcept C192157962 @default.
- W2070974158 hasConcept C2776330855 @default.
- W2070974158 hasConcept C2778918659 @default.
- W2070974158 hasConcept C39944091 @default.
- W2070974158 hasConcept C41625074 @default.
- W2070974158 hasConcept C43617362 @default.
- W2070974158 hasConcept C55493867 @default.
- W2070974158 hasConcept C86803240 @default.
- W2070974158 hasConcept C9603476 @default.
- W2070974158 hasConceptScore W2070974158C12554922 @default.
- W2070974158 hasConceptScore W2070974158C130316041 @default.
- W2070974158 hasConceptScore W2070974158C185592680 @default.
- W2070974158 hasConceptScore W2070974158C192157962 @default.
- W2070974158 hasConceptScore W2070974158C2776330855 @default.
- W2070974158 hasConceptScore W2070974158C2778918659 @default.
- W2070974158 hasConceptScore W2070974158C39944091 @default.
- W2070974158 hasConceptScore W2070974158C41625074 @default.
- W2070974158 hasConceptScore W2070974158C43617362 @default.
- W2070974158 hasConceptScore W2070974158C55493867 @default.
- W2070974158 hasConceptScore W2070974158C86803240 @default.
- W2070974158 hasConceptScore W2070974158C9603476 @default.
- W2070974158 hasIssue "1" @default.
- W2070974158 hasLocation W20709741581 @default.
- W2070974158 hasLocation W20709741582 @default.
- W2070974158 hasOpenAccess W2070974158 @default.
- W2070974158 hasPrimaryLocation W20709741581 @default.
- W2070974158 hasRelatedWork W1964058841 @default.
- W2070974158 hasRelatedWork W1970057409 @default.
- W2070974158 hasRelatedWork W1989589392 @default.
- W2070974158 hasRelatedWork W2006184290 @default.
- W2070974158 hasRelatedWork W2014983824 @default.
- W2070974158 hasRelatedWork W2016343967 @default.
- W2070974158 hasRelatedWork W2018520958 @default.
- W2070974158 hasRelatedWork W2082324319 @default.
- W2070974158 hasRelatedWork W2132656444 @default.
- W2070974158 hasRelatedWork W2461364449 @default.
- W2070974158 hasVolume "1152" @default.
- W2070974158 isParatext "false" @default.
- W2070974158 isRetracted "false" @default.
- W2070974158 magId "2070974158" @default.
- W2070974158 workType "article" @default.