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- W2070978045 endingPage "28" @default.
- W2070978045 startingPage "18" @default.
- W2070978045 abstract "Aberrant activation of the Wnt signaling pathway is a major trait of many human cancers. Due to its vast implications in tumorigenesis and progression, the Wnt pathway has attracted considerable attention at several molecular levels, also with respect to developing novel cancer therapeutics. Indeed, research in Wnt biology has recently provided numerous clues, and evidence is accumulating that the secreted Wnt antagonist Dickkopf-related protein 3 (Dkk-3) and its regulators may constitute interesting therapeutic targets in the most important human cancers. Based on the currently available literature, we here review the knowledge on the biological role of Dkk-3 as an antagonist of the Wnt signaling pathway, the involvement of Dkk-3 in several stages of tumor development, the genetic and epigenetic mechanisms disrupting DKK3 gene function in cancerous cells, and the potential clinical value of Dkk-3 expression/DKK3 promoter methylation as a biomarker and molecular target in cancer diseases. In conclusion, Dkk-3 rapidly emerges as a key player in human cancer with auspicious tumor suppressive capacities, most of all affecting apoptosis and proliferation. Its gene expression is frequently downregulated by promoter methylation in almost any solid and hematological tumor entity. Clinically, evidence is accumulating of Dkk-3 being both a potential tumor biomarker and effective anti-cancer agent. Although further research is needed, re-establishing Dkk-3 expression in cancer cells holds promise as novel targeted molecular tumor therapy." @default.
- W2070978045 created "2016-06-24" @default.
- W2070978045 creator A5042448145 @default.
- W2070978045 creator A5065806395 @default.
- W2070978045 date "2012-01-01" @default.
- W2070978045 modified "2023-10-13" @default.
- W2070978045 title "Targeting the Wnt pathway in cancer: The emerging role of Dickkopf-3" @default.
- W2070978045 cites W1502827089 @default.
- W2070978045 cites W153540453 @default.
- W2070978045 cites W1557541313 @default.
- W2070978045 cites W1564357553 @default.
- W2070978045 cites W1589352523 @default.
- W2070978045 cites W1878472746 @default.
- W2070978045 cites W1965262464 @default.
- W2070978045 cites W1967073403 @default.
- W2070978045 cites W1967137553 @default.
- W2070978045 cites W1970127746 @default.
- W2070978045 cites W1974497263 @default.
- W2070978045 cites W1976322888 @default.
- W2070978045 cites W1976889185 @default.
- W2070978045 cites W1978139448 @default.
- W2070978045 cites W1985389100 @default.
- W2070978045 cites W1986310096 @default.
- W2070978045 cites W1986515287 @default.
- W2070978045 cites W1986711493 @default.
- W2070978045 cites W1988999672 @default.
- W2070978045 cites W1991528589 @default.
- W2070978045 cites W1992127683 @default.
- W2070978045 cites W1992715477 @default.
- W2070978045 cites W1993369755 @default.
- W2070978045 cites W1994930074 @default.
- W2070978045 cites W1995061082 @default.
- W2070978045 cites W2003828339 @default.
- W2070978045 cites W2010055173 @default.
- W2070978045 cites W2010224007 @default.
- W2070978045 cites W2015519090 @default.
- W2070978045 cites W2019574453 @default.
- W2070978045 cites W2020590737 @default.
- W2070978045 cites W2022346609 @default.
- W2070978045 cites W2024985745 @default.
- W2070978045 cites W2025879648 @default.
- W2070978045 cites W2026398512 @default.
- W2070978045 cites W2027499156 @default.
- W2070978045 cites W2028947788 @default.
- W2070978045 cites W2029536633 @default.
- W2070978045 cites W2033667226 @default.
- W2070978045 cites W2035634736 @default.
- W2070978045 cites W2036523703 @default.
- W2070978045 cites W2038055986 @default.
- W2070978045 cites W2039215669 @default.
- W2070978045 cites W2039224704 @default.
- W2070978045 cites W2039758892 @default.
- W2070978045 cites W2042391568 @default.
- W2070978045 cites W2043474171 @default.
- W2070978045 cites W2044565426 @default.
- W2070978045 cites W2045595996 @default.
- W2070978045 cites W2049202209 @default.
- W2070978045 cites W2053403711 @default.
- W2070978045 cites W2054956467 @default.
- W2070978045 cites W2055808176 @default.
- W2070978045 cites W2057199920 @default.
- W2070978045 cites W2057703603 @default.
- W2070978045 cites W2058775452 @default.
- W2070978045 cites W2060796996 @default.
- W2070978045 cites W2064872225 @default.
- W2070978045 cites W2065517576 @default.
- W2070978045 cites W2067157368 @default.
- W2070978045 cites W2067775589 @default.
- W2070978045 cites W2067935707 @default.
- W2070978045 cites W2068568965 @default.
- W2070978045 cites W2068809543 @default.
- W2070978045 cites W2070469789 @default.
- W2070978045 cites W2074912732 @default.
- W2070978045 cites W2076745770 @default.
- W2070978045 cites W2081100760 @default.
- W2070978045 cites W2082788171 @default.
- W2070978045 cites W2084275797 @default.
- W2070978045 cites W2087314695 @default.
- W2070978045 cites W2088121357 @default.
- W2070978045 cites W2088429363 @default.
- W2070978045 cites W2091527193 @default.
- W2070978045 cites W2094053175 @default.
- W2070978045 cites W2094397925 @default.
- W2070978045 cites W2096865440 @default.
- W2070978045 cites W2102237045 @default.
- W2070978045 cites W2103285912 @default.
- W2070978045 cites W2108630708 @default.
- W2070978045 cites W2109076654 @default.
- W2070978045 cites W2115053373 @default.
- W2070978045 cites W2117013761 @default.
- W2070978045 cites W2117156715 @default.
- W2070978045 cites W2117716725 @default.
- W2070978045 cites W2136568746 @default.
- W2070978045 cites W2137146162 @default.
- W2070978045 cites W2140736127 @default.
- W2070978045 cites W2141435560 @default.
- W2070978045 cites W2143507493 @default.
- W2070978045 cites W2145753519 @default.