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• W2070997543 abstract "In vitro synthesis of IgG directed against HIV components was detected by ELISA and Western blot assay of lymphocyte culture supernatants. Lymphocytes from HIV-infected individuals spontaneously produced antibody against HIV proteins very early in culture, suggesting in vivo activation of HIV-specific antibody-forming cells. The frequency of circulating B cells spontaneously secreting HIV-specific IgG was very high in some cases, but spontaneous HIV-specific antibody synthesis was not accompanied by polyclonal reactivation of B-cell clones of different specificity. The pattern of specificity of the anti-HIV antibody produced in vitro did not reflect the serum pattern consistently. These findings indicate a new approach potentially useful for the study of the immunobiology of HIV infection. The possible implications of the in vitro production of HIV-specific antibody for the diagnosis, prognosis and clinical management of this infection are also discussed." @default.
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• W2070997543 date "1988-03-01" @default.
• W2070997543 modified "2023-10-16" @default.
• W2070997543 title "Spontaneous in vitro production of virus-specific antibody by lymphocytes from HIV-infected subjects" @default.
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• W2070997543 doi "https://doi.org/10.1016/0090-1229(88)90053-0" @default.
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