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- W2070999304 abstract "To clarify the role of tumor necrosis factor (TNF)-α on osteoblast functions in the presence of metal particles, two human osteoblast-like cell lines (MG-63 and SaOS-2) were cultured with TNF-α in the presence or absence of titanium particles in vitro. A combination of TNF-α and titanium particles showed additive effects on inhibition of cell proliferation and alkaline phosphatase production. On the other hand, production of interleukin-6, which is well known to induce osteoclastogenesis and to directly stimulate bone resorption, was additively stimulated by the combination of TNF-α and titanium particles. These results suggest that the association of TNF-α and titanium particles may play an important role in the pathogenesis of periprosthetic osteolysis through two different pathways: a reduced periprosthetic bone formation due to inhibition of osteoblast proliferation and alkaline phosphatase production, and osteoblast-mediated activation of osteoclastic bone resorption as suggested by the enhancement of interleukin-6 production. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 382–387, 2000." @default.
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- W2070999304 date "2000-01-01" @default.
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- W2070999304 title "Combined effect of titanium particles and TNF-? on the production of IL-6 by osteoblast-like cells" @default.
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- W2070999304 doi "https://doi.org/10.1002/1097-4636(200011)52:2<382::aid-jbm19>3.0.co;2-v" @default.
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