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- W2071000116 abstract "Epileptogenesis is defined as the process of developing epilepsy – a disorder characterized by recurrent seizures – following an initial insult. Neuronal death, aberrant synaptic plasticity and neuroinflammation play essential roles in epileptogenesis. An effective neuroprotective therapeutic agent should counteract one or, ideally, all the above-mentioned mechanisms. However, antiepileptic drugs obtainable nowadays can only suppress seizures, without antiepileptogenic effects. Matrix metalloproteinase-9 (MMP-9) is a member of matrix metalloproteinase (MMP) family that remodels the extracellular matrix. Recently, cumulative evidence indicates that MMP-9, a key participant in neuronal death, aberrant synaptic plasticity and neuroinflammation, is upregulated in experimental epilepsy models. Increased MMP-9 is also implicated in clinical epilepsy studies. Thus, we hypothesize that MMP-9 may be a novel therapeutic target for epilepsy and some agents, such as S24994, atorvastatin and minocycline, may be potential antiepileptogenic drugs." @default.
- W2071000116 created "2016-06-24" @default.
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- W2071000116 date "2011-02-01" @default.
- W2071000116 modified "2023-09-25" @default.
- W2071000116 title "Matrix metalloproteinase-9 may be a potential therapeutic target in epilepsy" @default.
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- W2071000116 doi "https://doi.org/10.1016/j.mehy.2010.09.013" @default.
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