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• W2071007063 abstract "The pineal hormone melatonin interacts with the neuroendocrine system via high affinity binding sites. The density of these receptors is increased after 72 h constant light or pinealectomy in both rat pars tuberalis and suprachiasmatic nuclei. The present results show that, in rat PT and SCN, this increase can be inversed by a single melatonin injection (50 micrograms s.c. in 0.1 ml NaCl, 4 h before sacrifice). At the time of sacrifice, plasma melatonin concentrations of injected animals were no longer significantly different when compared to control values. Thus, this observed effect is not a result of a receptor occupation, but demonstrates a direct regulation of melatonin receptors by melatonin itself." @default.
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• W2071007063 date "1993-01-01" @default.
• W2071007063 modified "2023-10-13" @default.
• W2071007063 title "Melatonin receptor density is regulated in rat pars tuberalis and suprachiasmatic nuclei by melatonin itself" @default.
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• W2071007063 doi "https://doi.org/10.1016/0006-8993(93)90256-m" @default.
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