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- W2071011352 abstract "Monoclonal anti-idiotype (Id) antibodies with specificities for determinants related to the antigen-binding sites of 3 BALB/c myeloma proteins, MOPC-460, HOPC-8 and J558, were used to study Id expression on murine lymphocytes. The monoclonal antibodies were shown to react only with Id structures associated with immunoglobulin on B cells. None of these 3 Id nor a VH Id, detected by a monoclonal antibody made against HOPC-8 heavy chain, were found on T cells. These Id were detected on splenic B cells in neonatal mice; the frequencies in normal, nude and germ-free mice were similar: MOPC-460 Id+: 1.05 ± 1.7/104 spleen cells, HOPC-8 Id+: 1.45 ± 1.2/104 and J558: 0.35 ± 0.6/104. Almost all Id+ cells bore surface IgM, a few expressed surface IgG. MOPC-460 Id+ IgG+ cells were mainly γ2a+ or γ2b+, whereas J558 and HOPC-8 Id+ IgG+ cells were γ3+." @default.
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- W2071011352 date "1984-01-01" @default.
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- W2071011352 title "Cellular expression of idiotopes defined by monoclonal antibodies" @default.
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- W2071011352 doi "https://doi.org/10.1002/eji.1830140708" @default.
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