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• W2071036315 abstract "ABSTRACT Hepatitis C virus (HCV) is considered to have a causative role in B-cell lymphoproliferative diseases, including B-cell lymphomas, in chronic virus carriers. Previous data from in vitro HCV-infected B-cell lines and peripheral blood mononuclear cells from HCV-positive individuals suggested that HCV might have a direct mutagenic effect on B cells, inducing mutations in the tumor suppressor gene TP53 and the proto-oncogenes BCL6 and CTNNB1 (β-catenin). To clarify whether HCV indeed has a mutagenic effect on B cells in vivo , we analyzed naive and memory B cells from the peripheral blood of four chronic HCV carriers and intrahepatic B cells from the livers of two HCV-positive patients for mutations in the three reported target genes. However, no mutations were found in the TP53 and CTNNB1 genes. For BCL6, which is a physiological target of the somatic hypermutation process in germinal-center B cells, the mutation levels identified were not higher than those reported in the respective B-cell subsets in healthy individuals. Hence, we conclude that in chronic HCV carriers, the virus does not generally induce mutations in the cancer-related genes TP53, CTNNB1, and BCL6 in B cells. Based on these findings, new targets have to be investigated as potential mediators of HCV-associated B-cell lymphomagenesis." @default.
• W2071036315 created "2016-06-24" @default.
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• W2071036315 date "2013-03-01" @default.
• W2071036315 modified "2023-09-27" @default.
• W2071036315 title "B Cells in Chronically Hepatitis C Virus-Infected Individuals Lack a Virus-Induced Mutation Signature in the<i>TP53</i>,<i>CTNNB1</i>, and<i>BCL6</i>Genes" @default.
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• W2071036315 doi "https://doi.org/10.1128/jvi.03081-12" @default.
• W2071036315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3571368" @default.
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