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• W2071036740 abstract "The hypothiocyanite ion (OSCN−) is the principal oxidation product of the salivary peroxidase-thiocyanate (SCN−)-hydrogen peroxide antimicrobial system. Supplementation of human saliva in vitro and in vivo with low amounts (< 1.0 mM) of hydrogen peroxide increase the concentration of salivary OSCN− (in vivo up to 0.3 mM). Elevated concentrations of OSCN− are strongly antimicrobial and may therefore be protective against dental caries. However, as OSCN− is a highly-reactive oxidizing agent, its possible toxic effect on human cells was studied using gingival flbroblasts as target cells. Concentrations of OSCN− (up to 300 μM) had no effect on [3H]-thymidine incorporation into the cells. However, fibroblasts were sensitive to peroxide so that 100 μ M of H2O2 caused over 80 per cent reduction in [3H]-thymidine incorporation. The toxicity of H2O2 could be entirely prevented by adding lacto-peroxidase and SCN− to the cell culture before the addition of peroxide. Thus, conversion of toxic H2O2 to non-toxic OSCN− in fibroblast culture by lactoperoxidase and SCN− suggests a dual role for the salivary peroxidase system: protection of human cells from H2O2 toxicity and antimicrobial action against oral pathogens. Furthermore, the elevated concentrations of OSCN − which produce inhibition of bacterial metabolism did not damage human cells." @default.
• W2071036740 created "2016-06-24" @default.
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• W2071036740 date "1984-01-01" @default.
• W2071036740 modified "2023-10-16" @default.
• W2071036740 title "The protective effect of peroxidase and thiocyanate against hydrogen peroxide toxicity assessed by the uptake of [3H]-thymidine by human gingival fibroblasts cultured in vitro" @default.
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• W2071036740 doi "https://doi.org/10.1016/0003-9969(84)90025-6" @default.
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