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- W2071036762 abstract "Out of 105 Philadelphia (Ph) positive chronic myeloid leukemia patients analyzed, six (5.7%) carried a variant Ph translocation, namely t(6;9;9;10;22)(q24;p13;q34;p15;q11); t(9;13;22)(q34;q21;q11);der(2)(2pter→2q31::9q21→9q34::22q11→22qter) and der(9)t(2;9) (9pter→9q21::2q31→2qter);t(7;9;22)(q11;q34;q11),14q+;t(7;9;22)(q35;q34;q11), and t(9;11;22) (q34;q13;q11), respectively. Five of these patients were analyzed with Southern blotting. Three of them showed an atypical molecular pattern; namely, the patient with t(9;13;22) showed no rearrangement in the breakpoint cluster region (bcr), the patient with t(7;9;22)(q35;q34;q11) showed a 3′ deletion, and the patient with t(7;9;22),14q+ showed a bcr rearrangement 3′ to the exon 4 of the M-BCR. Chromosome in situ hybridization studies demonstrated that in patient one, a two-step translocation occurred: the first step moved the 3′ bcr from chromosome 22 to chromosome 9, and the second moved the terminal part of 22q, carrying the c-sis protooncogene, to 10p. Variant Ph translocations appear to be associated with atypical molecular breakpoints." @default.
- W2071036762 created "2016-06-24" @default.
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- W2071036762 date "1989-10-01" @default.
- W2071036762 modified "2023-10-18" @default.
- W2071036762 title "Cytogenetic and molecular studies in patients with chronic myeloid leukemia and variant Philadelphia translocations" @default.
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- W2071036762 doi "https://doi.org/10.1016/0165-4608(89)90087-3" @default.
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