FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071039272> ?p ?o ?g. }

• W2071039272 endingPage "e29920" @default.
• W2071039272 startingPage "e29920" @default.
• W2071039272 abstract "c-Src activates Ras-MAPK/ERK signaling pathway and regulates cell migration, while trihydrophobin 1 (TH1) inhibits MAPK/ERK activation and cell migration through interaction with A-Raf and PAK1 and inhibiting their kinase activities. Here we show that c-Src interacts with TH1 by GST-pull down assay, coimmunoprecipitation and confocal microscopy assay. The interaction leads to phosphorylation of TH1 at Tyr-6 in vivo and in vitro. Phosphorylation of TH1 decreases its association with A-Raf and PAK1. Further study reveals that Tyr-6 phosphorylation of TH1 reduces its inhibition on MAPK/ERK signaling, enhances c-Src mediated cell migration. Moreover, induced tyrosine phosphorylation of TH1 has been found by EGF and estrogen treatments. Taken together, our findings demonstrate a novel mechanism for the comprehensive regulation of Ras/Raf/MEK/ERK signaling and cell migration involving tyrosine phosphorylation of TH1 by c-Src." @default.
• W2071039272 created "2016-06-24" @default.
• W2071039272 creator A5018911257 @default.
• W2071039272 creator A5019746575 @default.
• W2071039272 creator A5020099759 @default.
• W2071039272 creator A5020883926 @default.
• W2071039272 creator A5043824242 @default.
• W2071039272 creator A5044350152 @default.
• W2071039272 creator A5044861736 @default.
• W2071039272 creator A5056858826 @default.
• W2071039272 creator A5063368801 @default.
• W2071039272 creator A5066195990 @default.
• W2071039272 creator A5084269148 @default.
• W2071039272 creator A5084502351 @default.
• W2071039272 date "2012-01-06" @default.
• W2071039272 modified "2023-10-06" @default.
• W2071039272 title "Trihydrophobin 1 Phosphorylation by c-Src Regulates MAPK/ERK Signaling and Cell Migration" @default.
• W2071039272 cites W1662062786 @default.
• W2071039272 cites W1967265143 @default.
• W2071039272 cites W1969689864 @default.
• W2071039272 cites W1970213932 @default.
• W2071039272 cites W1977455794 @default.
• W2071039272 cites W1979197099 @default.
• W2071039272 cites W1988227656 @default.
• W2071039272 cites W2000170431 @default.
• W2071039272 cites W2013898467 @default.
• W2071039272 cites W2014280822 @default.
• W2071039272 cites W2014286995 @default.
• W2071039272 cites W2019143740 @default.
• W2071039272 cites W2020472510 @default.
• W2071039272 cites W2023187275 @default.
• W2071039272 cites W2023245305 @default.
• W2071039272 cites W2025757800 @default.
• W2071039272 cites W2026279585 @default.
• W2071039272 cites W2028124898 @default.
• W2071039272 cites W2032551621 @default.
• W2071039272 cites W2032909215 @default.
• W2071039272 cites W2034246730 @default.
• W2071039272 cites W2036988959 @default.
• W2071039272 cites W2040196938 @default.
• W2071039272 cites W2040412126 @default.
• W2071039272 cites W2046679772 @default.
• W2071039272 cites W2048209624 @default.
• W2071039272 cites W2048678993 @default.
• W2071039272 cites W2049360086 @default.
• W2071039272 cites W2049422138 @default.
• W2071039272 cites W2055901277 @default.
• W2071039272 cites W2056683808 @default.
• W2071039272 cites W2059552745 @default.
• W2071039272 cites W2069180517 @default.
• W2071039272 cites W2075191726 @default.
• W2071039272 cites W2075451080 @default.
• W2071039272 cites W2075612906 @default.
• W2071039272 cites W2079548558 @default.
• W2071039272 cites W2089379007 @default.
• W2071039272 cites W2100411328 @default.
• W2071039272 cites W2104337193 @default.
• W2071039272 cites W2110546905 @default.
• W2071039272 cites W2114909406 @default.
• W2071039272 cites W2138067522 @default.
• W2071039272 cites W2138231208 @default.
• W2071039272 cites W2142364395 @default.
• W2071039272 cites W2143140848 @default.
• W2071039272 cites W2153992286 @default.
• W2071039272 cites W2154766134 @default.
• W2071039272 cites W2155490728 @default.
• W2071039272 cites W2162082053 @default.
• W2071039272 cites W25083591 @default.
• W2071039272 cites W4254123044 @default.
• W2071039272 doi "https://doi.org/10.1371/journal.pone.0029920" @default.
• W2071039272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253115" @default.
• W2071039272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22238675" @default.
• W2071039272 hasPublicationYear "2012" @default.
• W2071039272 type Work @default.
• W2071039272 sameAs 2071039272 @default.
• W2071039272 citedByCount "20" @default.
• W2071039272 countsByYear W20710392722012 @default.
• W2071039272 countsByYear W20710392722013 @default.
• W2071039272 countsByYear W20710392722014 @default.
• W2071039272 countsByYear W20710392722017 @default.
• W2071039272 countsByYear W20710392722018 @default.
• W2071039272 countsByYear W20710392722020 @default.
• W2071039272 countsByYear W20710392722022 @default.
• W2071039272 crossrefType "journal-article" @default.
• W2071039272 hasAuthorship W2071039272A5018911257 @default.
• W2071039272 hasAuthorship W2071039272A5019746575 @default.
• W2071039272 hasAuthorship W2071039272A5020099759 @default.
• W2071039272 hasAuthorship W2071039272A5020883926 @default.
• W2071039272 hasAuthorship W2071039272A5043824242 @default.
• W2071039272 hasAuthorship W2071039272A5044350152 @default.
• W2071039272 hasAuthorship W2071039272A5044861736 @default.
• W2071039272 hasAuthorship W2071039272A5056858826 @default.
• W2071039272 hasAuthorship W2071039272A5063368801 @default.
• W2071039272 hasAuthorship W2071039272A5066195990 @default.
• W2071039272 hasAuthorship W2071039272A5084269148 @default.
• W2071039272 hasAuthorship W2071039272A5084502351 @default.
• W2071039272 hasBestOaLocation W20710392721 @default.
• W2071039272 hasConcept C108636557 @default.

• next