Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071041419> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2071041419 endingPage "154" @default.
- W2071041419 startingPage "154" @default.
- W2071041419 abstract "Monitored anaesthesia care (MAC) is meant for procedures under local anaesthesia. Various drugs have been used for this purpose. The recently introduced alpha2 agonist, dexmedetomidine provides conscious sedation with adequate analgesia and minimal respiratory depression. Hence, the safety and efficacy of two doses of dexmedetomidine for sedation and analgesia were evaluated.A total of 90 patients were distributed in three groups of 30 each: Dexmedetomidine 0.5 μg/kg (DL), dexmedetomidine 1.0 μg/kg (DH) and normal saline (C). The initial loading dose was followed by maintenance infusion of 0.2-0.7 μg/kg/h of dexmedetomidine or equivalent volume of saline. Study drug was started at least 15 min before placement of local anaesthesia. Drugs were titrated to a target level of sedation (=3 on Ramsay sedation scale [RSS]). Midazolam 0.02 mg/kg for RSS < 3 and fentanyl 0.5 μg/kg were supplemented as required. The statistical analysis was performed using Chi-square test and mean and anova analysis.In groups DL and DH fewer patients required supplemental midazolam, 56.7% (17/30) and 40% (12/30), compared with control, where 86.7% (26/30)needed midazolam supplements. P = 0.000. Both groups DL and DH required significantly less fentanyl (84.8 and 83.9 μg) versus control (144.2 μg). There was significantly increased ease of achieving and maintaining targeted sedation and analgesia in both dexmedetomidine groups when compared with placebo (P = 0.001). Adverse events observed with dexmedetomidine were bradycardia and hypotension.Dexmedetomidine in the doses studied was considered safe and effective sedative and analgesic for patients undergoing procedures under MAC." @default.
- W2071041419 created "2016-06-24" @default.
- W2071041419 creator A5038728019 @default.
- W2071041419 creator A5048768829 @default.
- W2071041419 creator A5052730137 @default.
- W2071041419 creator A5065895931 @default.
- W2071041419 date "2014-01-01" @default.
- W2071041419 modified "2023-09-27" @default.
- W2071041419 title "Dexmedetomidine ameliorates monitored anaesthesia care" @default.
- W2071041419 cites W2000493820 @default.
- W2071041419 cites W2017573472 @default.
- W2071041419 cites W2020936753 @default.
- W2071041419 cites W2031647726 @default.
- W2071041419 cites W2034557139 @default.
- W2071041419 cites W2039461490 @default.
- W2071041419 cites W2041322579 @default.
- W2071041419 cites W2062110225 @default.
- W2071041419 cites W2125134115 @default.
- W2071041419 cites W2129401965 @default.
- W2071041419 cites W2130809999 @default.
- W2071041419 cites W2160041196 @default.
- W2071041419 cites W2168312394 @default.
- W2071041419 doi "https://doi.org/10.4103/0019-5049.130816" @default.
- W2071041419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4050931" @default.
- W2071041419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24963179" @default.
- W2071041419 hasPublicationYear "2014" @default.
- W2071041419 type Work @default.
- W2071041419 sameAs 2071041419 @default.
- W2071041419 citedByCount "6" @default.
- W2071041419 countsByYear W20710414192014 @default.
- W2071041419 countsByYear W20710414192015 @default.
- W2071041419 countsByYear W20710414192016 @default.
- W2071041419 countsByYear W20710414192020 @default.
- W2071041419 crossrefType "journal-article" @default.
- W2071041419 hasAuthorship W2071041419A5038728019 @default.
- W2071041419 hasAuthorship W2071041419A5048768829 @default.
- W2071041419 hasAuthorship W2071041419A5052730137 @default.
- W2071041419 hasAuthorship W2071041419A5065895931 @default.
- W2071041419 hasBestOaLocation W20710414191 @default.
- W2071041419 hasConcept C126322002 @default.
- W2071041419 hasConcept C2776814716 @default.
- W2071041419 hasConcept C2777397205 @default.
- W2071041419 hasConcept C2777495988 @default.
- W2071041419 hasConcept C2777953023 @default.
- W2071041419 hasConcept C2778000748 @default.
- W2071041419 hasConcept C2781072394 @default.
- W2071041419 hasConcept C2781302539 @default.
- W2071041419 hasConcept C35294091 @default.
- W2071041419 hasConcept C42219234 @default.
- W2071041419 hasConcept C71924100 @default.
- W2071041419 hasConcept C84393581 @default.
- W2071041419 hasConceptScore W2071041419C126322002 @default.
- W2071041419 hasConceptScore W2071041419C2776814716 @default.
- W2071041419 hasConceptScore W2071041419C2777397205 @default.
- W2071041419 hasConceptScore W2071041419C2777495988 @default.
- W2071041419 hasConceptScore W2071041419C2777953023 @default.
- W2071041419 hasConceptScore W2071041419C2778000748 @default.
- W2071041419 hasConceptScore W2071041419C2781072394 @default.
- W2071041419 hasConceptScore W2071041419C2781302539 @default.
- W2071041419 hasConceptScore W2071041419C35294091 @default.
- W2071041419 hasConceptScore W2071041419C42219234 @default.
- W2071041419 hasConceptScore W2071041419C71924100 @default.
- W2071041419 hasConceptScore W2071041419C84393581 @default.
- W2071041419 hasIssue "2" @default.
- W2071041419 hasLocation W20710414191 @default.
- W2071041419 hasLocation W20710414192 @default.
- W2071041419 hasLocation W20710414193 @default.
- W2071041419 hasLocation W20710414194 @default.
- W2071041419 hasLocation W20710414195 @default.
- W2071041419 hasOpenAccess W2071041419 @default.
- W2071041419 hasPrimaryLocation W20710414191 @default.
- W2071041419 hasRelatedWork W1990997597 @default.
- W2071041419 hasRelatedWork W2186398722 @default.
- W2071041419 hasRelatedWork W2333479277 @default.
- W2071041419 hasRelatedWork W2520630385 @default.
- W2071041419 hasRelatedWork W2884670186 @default.
- W2071041419 hasRelatedWork W3030850133 @default.
- W2071041419 hasRelatedWork W3153296609 @default.
- W2071041419 hasRelatedWork W4200501500 @default.
- W2071041419 hasRelatedWork W4280587118 @default.
- W2071041419 hasRelatedWork W4306405655 @default.
- W2071041419 hasVolume "58" @default.
- W2071041419 isParatext "false" @default.
- W2071041419 isRetracted "false" @default.
- W2071041419 magId "2071041419" @default.
- W2071041419 workType "article" @default.