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• W2071051432 startingPage "1397" @default.
• W2071051432 abstract "The adult respiratory distress syndrome (ARDS) is a devastating clinical illness characterized by refractory hypoxemia and high-permeability pulmonary edema. Reactive oxygen species such as hydrogen peroxide and hypochlorous acid may play a key role in the pathogenesis of the acute lung injury. Glutathione (GSH) is a tripeptide that is able to react with and effectively neutralize oxidants such as hydrogen peroxide and hypochlorous acid. The present study found that the alveolar epithelial lining fluid of patients with ARDS was deficient in total GSH compared to normal subjects (21.7μmol ± 7.8 μmol vs 91.8μmo1 ± 14.5μmo1; p = 0.002). In addition, if GSH was measured in unconcentrated bronchoalveolar lavage (BAL) fluid and indexed to total BAL protein, there was also a deficiency in patients with ARDS compared to normal subjects (0.004 ± 0.003 nmol of CSH per microgram of total protein vs 0.026 ± 0.005 nmol of GSH per microgram of total protein; p=0.002). Since patients with ARDS are subjected to an increased burden of oxidants in the alveolar fluid, principally released by recruited neutrophils, this deficiency of CSH may predispose these patients to enhanced lung cell injury. The adult respiratory distress syndrome (ARDS) is a devastating clinical illness characterized by refractory hypoxemia and high-permeability pulmonary edema. Reactive oxygen species such as hydrogen peroxide and hypochlorous acid may play a key role in the pathogenesis of the acute lung injury. Glutathione (GSH) is a tripeptide that is able to react with and effectively neutralize oxidants such as hydrogen peroxide and hypochlorous acid. The present study found that the alveolar epithelial lining fluid of patients with ARDS was deficient in total GSH compared to normal subjects (21.7μmol ± 7.8 μmol vs 91.8μmo1 ± 14.5μmo1; p = 0.002). In addition, if GSH was measured in unconcentrated bronchoalveolar lavage (BAL) fluid and indexed to total BAL protein, there was also a deficiency in patients with ARDS compared to normal subjects (0.004 ± 0.003 nmol of CSH per microgram of total protein vs 0.026 ± 0.005 nmol of GSH per microgram of total protein; p=0.002). Since patients with ARDS are subjected to an increased burden of oxidants in the alveolar fluid, principally released by recruited neutrophils, this deficiency of CSH may predispose these patients to enhanced lung cell injury." @default.
• W2071051432 created "2016-06-24" @default.
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• W2071051432 date "1991-11-01" @default.
• W2071051432 modified "2023-10-14" @default.
• W2071051432 title "Deficiency of Alveolar Fluid Glutathione in Patients with Sepsis and the Adult Respiratory Distress Syndrome" @default.
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• W2071051432 doi "https://doi.org/10.1378/chest.100.5.1397" @default.
• W2071051432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1935300" @default.
• W2071051432 hasPublicationYear "1991" @default.
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