FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071055835> ?p ?o ?g. }

• W2071055835 endingPage "2046" @default.
• W2071055835 startingPage "2043" @default.
• W2071055835 abstract "Three dimethyl-L-tyrosine (Dmt) based peptide analogues were identified in a previous study as excellent agonists for the mu-opioid receptor showing very low K(i) values and good in vivo antinociceptive activity upon intracerebroventricular administration to mice. This activity decreased markedly when the compounds were delivered subcutaneously or orally. To establish the cause of this decrease of activity the apparent permeability across Caco-2 cell monolayers of each compound and their relative stability to the digestive enzymes present in the cell line has been determined and compared to that of the native peptide endomorphin 2. The compounds' permeabilities clearly correlate with their increasing lipophilicity suggesting that the analogues cross the monolayer via passive diffusion and the results show that the compound with high K(i) value for the mu-receptor (K(i)mu=0.114 nM) exhibited the highest permeability suggesting that this may be the better lead compound despite the lower binding affinity than that of compound 2 or 3." @default.
• W2071055835 created "2016-06-24" @default.
• W2071055835 creator A5008581557 @default.
• W2071055835 creator A5019064611 @default.
• W2071055835 creator A5030809281 @default.
• W2071055835 creator A5066801642 @default.
• W2071055835 creator A5076387312 @default.
• W2071055835 creator A5084009964 @default.
• W2071055835 date "2007-04-01" @default.
• W2071055835 modified "2023-09-24" @default.
• W2071055835 title "Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide" @default.
• W2071055835 cites W1755208670 @default.
• W2071055835 cites W1974963512 @default.
• W2071055835 cites W1979196526 @default.
• W2071055835 cites W1980688163 @default.
• W2071055835 cites W1992229282 @default.
• W2071055835 cites W1994158160 @default.
• W2071055835 cites W2006840751 @default.
• W2071055835 cites W2020603101 @default.
• W2071055835 cites W2038181880 @default.
• W2071055835 cites W2041391634 @default.
• W2071055835 cites W2042342325 @default.
• W2071055835 cites W2052804114 @default.
• W2071055835 cites W2055743299 @default.
• W2071055835 cites W2061241957 @default.
• W2071055835 cites W2068981657 @default.
• W2071055835 cites W2072755794 @default.
• W2071055835 cites W2074995652 @default.
• W2071055835 cites W2082881419 @default.
• W2071055835 cites W2084375116 @default.
• W2071055835 cites W2085156914 @default.
• W2071055835 cites W2086747459 @default.
• W2071055835 cites W2095060296 @default.
• W2071055835 cites W2132287967 @default.
• W2071055835 cites W2140910183 @default.
• W2071055835 cites W2145975509 @default.
• W2071055835 cites W2203774030 @default.
• W2071055835 cites W2952084650 @default.
• W2071055835 doi "https://doi.org/10.1016/j.bmcl.2007.01.051" @default.
• W2071055835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17300932" @default.
• W2071055835 hasPublicationYear "2007" @default.
• W2071055835 type Work @default.
• W2071055835 sameAs 2071055835 @default.
• W2071055835 citedByCount "9" @default.
• W2071055835 countsByYear W20710558352012 @default.
• W2071055835 countsByYear W20710558352013 @default.
• W2071055835 countsByYear W20710558352014 @default.
• W2071055835 countsByYear W20710558352023 @default.
• W2071055835 crossrefType "journal-article" @default.
• W2071055835 hasAuthorship W2071055835A5008581557 @default.
• W2071055835 hasAuthorship W2071055835A5019064611 @default.
• W2071055835 hasAuthorship W2071055835A5030809281 @default.
• W2071055835 hasAuthorship W2071055835A5066801642 @default.
• W2071055835 hasAuthorship W2071055835A5076387312 @default.
• W2071055835 hasAuthorship W2071055835A5084009964 @default.
• W2071055835 hasConcept C120882062 @default.
• W2071055835 hasConcept C12554922 @default.
• W2071055835 hasConcept C150903083 @default.
• W2071055835 hasConcept C170493617 @default.
• W2071055835 hasConcept C185592680 @default.
• W2071055835 hasConcept C201399114 @default.
• W2071055835 hasConcept C202751555 @default.
• W2071055835 hasConcept C207001950 @default.
• W2071055835 hasConcept C2779281246 @default.
• W2071055835 hasConcept C2779886867 @default.
• W2071055835 hasConcept C2781063702 @default.
• W2071055835 hasConcept C41625074 @default.
• W2071055835 hasConcept C55493867 @default.
• W2071055835 hasConcept C71240020 @default.
• W2071055835 hasConcept C71924100 @default.
• W2071055835 hasConcept C86803240 @default.
• W2071055835 hasConcept C88016717 @default.
• W2071055835 hasConcept C98274493 @default.
• W2071055835 hasConceptScore W2071055835C120882062 @default.
• W2071055835 hasConceptScore W2071055835C12554922 @default.
• W2071055835 hasConceptScore W2071055835C150903083 @default.
• W2071055835 hasConceptScore W2071055835C170493617 @default.
• W2071055835 hasConceptScore W2071055835C185592680 @default.
• W2071055835 hasConceptScore W2071055835C201399114 @default.
• W2071055835 hasConceptScore W2071055835C202751555 @default.
• W2071055835 hasConceptScore W2071055835C207001950 @default.
• W2071055835 hasConceptScore W2071055835C2779281246 @default.
• W2071055835 hasConceptScore W2071055835C2779886867 @default.
• W2071055835 hasConceptScore W2071055835C2781063702 @default.
• W2071055835 hasConceptScore W2071055835C41625074 @default.
• W2071055835 hasConceptScore W2071055835C55493867 @default.
• W2071055835 hasConceptScore W2071055835C71240020 @default.
• W2071055835 hasConceptScore W2071055835C71924100 @default.
• W2071055835 hasConceptScore W2071055835C86803240 @default.
• W2071055835 hasConceptScore W2071055835C88016717 @default.
• W2071055835 hasConceptScore W2071055835C98274493 @default.
• W2071055835 hasIssue "7" @default.
• W2071055835 hasLocation W20710558351 @default.
• W2071055835 hasLocation W20710558352 @default.
• W2071055835 hasOpenAccess W2071055835 @default.
• W2071055835 hasPrimaryLocation W20710558351 @default.
• W2071055835 hasRelatedWork W1270150154 @default.
• W2071055835 hasRelatedWork W141444575 @default.

• next