Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071058837> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2071058837 endingPage "466" @default.
- W2071058837 startingPage "462" @default.
- W2071058837 abstract "OBJECTIVE: Chitin is a recognition element for tissue infiltration by innate cells implicated in allergy and helminth immunity, and this process can be negatively regulated by vertebrate chitinases. Acidic mammalian chitinase (AMCase) and chitotriosidase (ChT) have chitinolytic activity, but little is known about their roles in nasal polyps. SUBJECTS AND METHODS: Nineteen subjects with nasal polyps and 12 subjects with deviated nasal septums were recruited to obtain inferior turbinate mucosa samples. The expression levels of AMCase and ChT were compared in nasal polyp and inferior turbinate tissue samples. The tissue samples were analyzed by reverse transcription-polymerase chain reaction, Western blotting, and immunohistochemical staining. RESULTS: AMCase and ChT were detected in all nasal polyps and inferior turbinate tissues. AMCase and ChT messenger RNA and protein expression were significantly higher in nasal polyps than in inferior turbinate tissues. In nasal polyps, AMCase-positive and ChT-positive cells were detected in the epithelium, inflammatory cells, and submucosal gland. CONCLUSIONS: AMCase and ChT may be important mediators in the pathogenesis of nasal polyps. Nasal polyps appear to have elevated levels of chitinases, and the presence or growth of chitin-containing pathogens might enhance chitinase expression, resulting in nasal polyp formation and growth in susceptible individuals." @default.
- W2071058837 created "2016-06-24" @default.
- W2071058837 creator A5030707488 @default.
- W2071058837 creator A5033813084 @default.
- W2071058837 creator A5083484723 @default.
- W2071058837 creator A5085847124 @default.
- W2071058837 creator A5086227577 @default.
- W2071058837 date "2009-10-01" @default.
- W2071058837 modified "2023-09-27" @default.
- W2071058837 title "Role of Acidic Mammalian Chitinase and Chitotriosidase in Nasal Polyps" @default.
- W2071058837 cites W1945479327 @default.
- W2071058837 cites W1999350965 @default.
- W2071058837 cites W2025131995 @default.
- W2071058837 cites W2029041605 @default.
- W2071058837 cites W2036539586 @default.
- W2071058837 cites W2055968806 @default.
- W2071058837 cites W2056975585 @default.
- W2071058837 cites W2057488799 @default.
- W2071058837 cites W2061279709 @default.
- W2071058837 cites W2072705074 @default.
- W2071058837 cites W2075858546 @default.
- W2071058837 cites W2084676679 @default.
- W2071058837 cites W2090919511 @default.
- W2071058837 cites W2113376388 @default.
- W2071058837 cites W2133111763 @default.
- W2071058837 cites W2149760554 @default.
- W2071058837 cites W2160806937 @default.
- W2071058837 doi "https://doi.org/10.1016/j.otohns.2009.06.013" @default.
- W2071058837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19786213" @default.
- W2071058837 hasPublicationYear "2009" @default.
- W2071058837 type Work @default.
- W2071058837 sameAs 2071058837 @default.
- W2071058837 citedByCount "13" @default.
- W2071058837 countsByYear W20710588372012 @default.
- W2071058837 countsByYear W20710588372013 @default.
- W2071058837 countsByYear W20710588372014 @default.
- W2071058837 countsByYear W20710588372016 @default.
- W2071058837 countsByYear W20710588372018 @default.
- W2071058837 countsByYear W20710588372021 @default.
- W2071058837 crossrefType "journal-article" @default.
- W2071058837 hasAuthorship W2071058837A5030707488 @default.
- W2071058837 hasAuthorship W2071058837A5033813084 @default.
- W2071058837 hasAuthorship W2071058837A5083484723 @default.
- W2071058837 hasAuthorship W2071058837A5085847124 @default.
- W2071058837 hasAuthorship W2071058837A5086227577 @default.
- W2071058837 hasConcept C104317684 @default.
- W2071058837 hasConcept C142724271 @default.
- W2071058837 hasConcept C203014093 @default.
- W2071058837 hasConcept C204232928 @default.
- W2071058837 hasConcept C2780778831 @default.
- W2071058837 hasConcept C2780942790 @default.
- W2071058837 hasConcept C2781390199 @default.
- W2071058837 hasConcept C55493867 @default.
- W2071058837 hasConcept C59377437 @default.
- W2071058837 hasConcept C71924100 @default.
- W2071058837 hasConcept C85265743 @default.
- W2071058837 hasConcept C86803240 @default.
- W2071058837 hasConceptScore W2071058837C104317684 @default.
- W2071058837 hasConceptScore W2071058837C142724271 @default.
- W2071058837 hasConceptScore W2071058837C203014093 @default.
- W2071058837 hasConceptScore W2071058837C204232928 @default.
- W2071058837 hasConceptScore W2071058837C2780778831 @default.
- W2071058837 hasConceptScore W2071058837C2780942790 @default.
- W2071058837 hasConceptScore W2071058837C2781390199 @default.
- W2071058837 hasConceptScore W2071058837C55493867 @default.
- W2071058837 hasConceptScore W2071058837C59377437 @default.
- W2071058837 hasConceptScore W2071058837C71924100 @default.
- W2071058837 hasConceptScore W2071058837C85265743 @default.
- W2071058837 hasConceptScore W2071058837C86803240 @default.
- W2071058837 hasIssue "4" @default.
- W2071058837 hasLocation W20710588371 @default.
- W2071058837 hasLocation W20710588372 @default.
- W2071058837 hasOpenAccess W2071058837 @default.
- W2071058837 hasPrimaryLocation W20710588371 @default.
- W2071058837 hasRelatedWork W1988051734 @default.
- W2071058837 hasRelatedWork W2254469401 @default.
- W2071058837 hasRelatedWork W2349492056 @default.
- W2071058837 hasRelatedWork W2361228875 @default.
- W2071058837 hasRelatedWork W2364823688 @default.
- W2071058837 hasRelatedWork W2376395679 @default.
- W2071058837 hasRelatedWork W2408745319 @default.
- W2071058837 hasRelatedWork W2422959871 @default.
- W2071058837 hasRelatedWork W2495397751 @default.
- W2071058837 hasRelatedWork W3152336362 @default.
- W2071058837 hasVolume "141" @default.
- W2071058837 isParatext "false" @default.
- W2071058837 isRetracted "false" @default.
- W2071058837 magId "2071058837" @default.
- W2071058837 workType "article" @default.