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• W2071065870 abstract "L’osteonecrosi dei mascellari (ONJ) è un effetto collaterale della terapia con bisfosfonati (BPT), descritto a partire dal 2003. L’eziologia della BRONJ rimane sconosciuta e la patogenesi multifattoriale sembra collegata a diversi fattori locali e generali. Vari gruppi di esperti hanno sviluppato protocolli preventivi per agevolare gli specialisti coinvolti nella gestione multidisciplinare dei pazienti affetti da BRONJ. Scopo di questo lavoro è fornire una rassegna concisa della letteratura, unitamente alla descrizione dell’esperienza dell’Università degli Studi di Parma su 160 pazienti sottoposti a BPT per patologie oncologiche e non oncologiche. 139 siti BRONJ sono stati trattati con 5 approcci diversi e, quindi, sottoclassificati in 5 differenti gruppi: G1 (28 siti), siti BRONJ trattati con sola terapia medica; G2 (32 siti), siti BRONJ trattati con terapia medica e Low Level Laser Therapy (LLLT); G3 (17 siti), siti BRONJ trattati con terapia medica e chirurgia tradizionale; G4 (33 siti), siti BRONJ trattati con terapia medica, chirurgia tradizionale e LLLT; G5 (29 siti), siti BRONJ trattati con terapia medica, chirurgia laser-assistita e LLLT. In termini di miglioramento clinico, una differenza statisticamente significativa è stata riscontrata tra i differenti gruppi che avevano ricevuto più di un trattamento e quello trattato con la sola terapia medica; in termini di guarigione completa, l’introduzione nei protocolli terapeutici dell’approccio laser-assistito e dell’approccio chirurgico risulta correlata a migliori risultati terapeutici. Osteonecrosis of the jaw (ONJ) is a side effect of bisphosphonate therapy (BPT) that was first described in 2003. The etiology of BPT-associated ONJ (BRONJ) remains unknown, but the pathogenesis seems to be related to multiple local and general factors. Several groups of experts have developed prevention protocols to facilitate specialists involved in the multidisciplinary management of patients with BRONJ. This paper provides a concise review of the literature on BRONJ and describes our experience at the University of Parma with 160 patients who received BPT for neoplastic and non-neoplastic diseases. 139 BRONJ sites in 160 patients were treated with 5 different approaches, as follows: Group 1, 28 sites treated with medical therapy alone; Group 2, 32 sites treated with medical therapy and Low-Level Laser Therapy (LLLT); Group 3, 17 sites treated with medical therapy and conventional surgery; Group 4, 33 sites treated with medical therapy, surgery, and traditional LLLT; and Group 5, 29 sites treated with medical therapy, laser-assisted surgery, and LLLT. In terms of clinical improvement, statistically significant differences were found between the different treatment groups and those treated with medical therapy alone. The introduction of laser-assisted therapy and surgical approaches seem to produce better results in terms of complete healing." @default.
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• W2071065870 date "2012-01-01" @default.
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• W2071065870 title "Osteonecrosi dei mascellari e bisfosfonati: terapia e follow-up a lungo termine in 160 pazienti" @default.
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• W2071065870 doi "https://doi.org/10.1016/j.cadmos.2011.05.007" @default.
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