Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071068913> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2071068913 endingPage "1813" @default.
- W2071068913 startingPage "1804" @default.
- W2071068913 abstract "To define the mechanisms by which antiestrogens inhibit breast cancer cell proliferation, the effects of the antiestrogen ICI 182780 on G1 cyclins and their cyclin-dependent kinase (CDK) partners were investigated in MCF-7 cells. Inhibition of entry into S phase became evident 9 h after treatment, with the proportion of cells in S phase reaching a minimum by 24 h. ICI 182780 increased the proportion of the hypophosphorylated, growth inhibitory form of the retinoblastoma protein (pRB). This change began at 4-6 h, preceding effects on S phase. This suggests that there are early effects on the activities of CDKs that target pRB that are not merely a consequence of changes in cell cycle progression. The kinase activity of Cdk2 decreased to low levels at 18-24 h when changes in S phase and pRB phosphorylation were well advanced. An earlier effect was seen on kinase activity associated with immunoprecipitated cyclin D1, which was reduced approximately 40% by 12 h, with further decreases at 18-24 h. Cdk2 and Cdk4 protein levels remained constant over 24 h. Cyclin D1 messenger RNA and protein were down-regulated by ICI 182780 from 2 h, with levels halved at 8 h. ICI 182780 also increased the expression of the CDK inhibitors p27KIP1 and p21WAF1/CIP1 at later times. These observations are compatible with the hypothesis that antiestrogens block entry of cells into S phase and inhibit cell proliferation as the consequence of an early decline in pRB phosphorylation contributed to by reduced cyclin D1/Cdk4 activity. At later times, increased CDK inhibitor abundance may act to repress Cdk2 and Cdk4 activities, causing additional reductions in pRB phosphorylation, thus maintaining the antiestrogen blockade of cell cycle progression." @default.
- W2071068913 created "2016-06-24" @default.
- W2071068913 creator A5001667624 @default.
- W2071068913 creator A5023643377 @default.
- W2071068913 creator A5027248689 @default.
- W2071068913 creator A5029330166 @default.
- W2071068913 creator A5067798845 @default.
- W2071068913 creator A5079353631 @default.
- W2071068913 date "1995-12-01" @default.
- W2071068913 modified "2023-10-14" @default.
- W2071068913 title "Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation." @default.
- W2071068913 doi "https://doi.org/10.1210/mend.9.12.8614416" @default.
- W2071068913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8614416" @default.
- W2071068913 hasPublicationYear "1995" @default.
- W2071068913 type Work @default.
- W2071068913 sameAs 2071068913 @default.
- W2071068913 citedByCount "94" @default.
- W2071068913 countsByYear W20710689132012 @default.
- W2071068913 countsByYear W20710689132013 @default.
- W2071068913 countsByYear W20710689132014 @default.
- W2071068913 countsByYear W20710689132015 @default.
- W2071068913 countsByYear W20710689132016 @default.
- W2071068913 countsByYear W20710689132018 @default.
- W2071068913 countsByYear W20710689132019 @default.
- W2071068913 countsByYear W20710689132021 @default.
- W2071068913 countsByYear W20710689132022 @default.
- W2071068913 crossrefType "journal-article" @default.
- W2071068913 hasAuthorship W2071068913A5001667624 @default.
- W2071068913 hasAuthorship W2071068913A5023643377 @default.
- W2071068913 hasAuthorship W2071068913A5027248689 @default.
- W2071068913 hasAuthorship W2071068913A5029330166 @default.
- W2071068913 hasAuthorship W2071068913A5067798845 @default.
- W2071068913 hasAuthorship W2071068913A5079353631 @default.
- W2071068913 hasBestOaLocation W20710689131 @default.
- W2071068913 hasConcept C11882975 @default.
- W2071068913 hasConcept C120089663 @default.
- W2071068913 hasConcept C121608353 @default.
- W2071068913 hasConcept C124320809 @default.
- W2071068913 hasConcept C1491633281 @default.
- W2071068913 hasConcept C16438837 @default.
- W2071068913 hasConcept C184235292 @default.
- W2071068913 hasConcept C199835354 @default.
- W2071068913 hasConcept C2776062698 @default.
- W2071068913 hasConcept C2776067312 @default.
- W2071068913 hasConcept C29537977 @default.
- W2071068913 hasConcept C502942594 @default.
- W2071068913 hasConcept C51853150 @default.
- W2071068913 hasConcept C530470458 @default.
- W2071068913 hasConcept C54355233 @default.
- W2071068913 hasConcept C55493867 @default.
- W2071068913 hasConcept C82495950 @default.
- W2071068913 hasConcept C84606932 @default.
- W2071068913 hasConcept C86803240 @default.
- W2071068913 hasConcept C94561458 @default.
- W2071068913 hasConcept C95444343 @default.
- W2071068913 hasConcept C97029542 @default.
- W2071068913 hasConceptScore W2071068913C11882975 @default.
- W2071068913 hasConceptScore W2071068913C120089663 @default.
- W2071068913 hasConceptScore W2071068913C121608353 @default.
- W2071068913 hasConceptScore W2071068913C124320809 @default.
- W2071068913 hasConceptScore W2071068913C1491633281 @default.
- W2071068913 hasConceptScore W2071068913C16438837 @default.
- W2071068913 hasConceptScore W2071068913C184235292 @default.
- W2071068913 hasConceptScore W2071068913C199835354 @default.
- W2071068913 hasConceptScore W2071068913C2776062698 @default.
- W2071068913 hasConceptScore W2071068913C2776067312 @default.
- W2071068913 hasConceptScore W2071068913C29537977 @default.
- W2071068913 hasConceptScore W2071068913C502942594 @default.
- W2071068913 hasConceptScore W2071068913C51853150 @default.
- W2071068913 hasConceptScore W2071068913C530470458 @default.
- W2071068913 hasConceptScore W2071068913C54355233 @default.
- W2071068913 hasConceptScore W2071068913C55493867 @default.
- W2071068913 hasConceptScore W2071068913C82495950 @default.
- W2071068913 hasConceptScore W2071068913C84606932 @default.
- W2071068913 hasConceptScore W2071068913C86803240 @default.
- W2071068913 hasConceptScore W2071068913C94561458 @default.
- W2071068913 hasConceptScore W2071068913C95444343 @default.
- W2071068913 hasConceptScore W2071068913C97029542 @default.
- W2071068913 hasIssue "12" @default.
- W2071068913 hasLocation W20710689131 @default.
- W2071068913 hasLocation W20710689132 @default.
- W2071068913 hasOpenAccess W2071068913 @default.
- W2071068913 hasPrimaryLocation W20710689131 @default.
- W2071068913 hasRelatedWork W1964534615 @default.
- W2071068913 hasRelatedWork W2035073888 @default.
- W2071068913 hasRelatedWork W2056794794 @default.
- W2071068913 hasRelatedWork W2071068913 @default.
- W2071068913 hasRelatedWork W2111450457 @default.
- W2071068913 hasRelatedWork W2116885808 @default.
- W2071068913 hasRelatedWork W2162793908 @default.
- W2071068913 hasRelatedWork W2316647275 @default.
- W2071068913 hasRelatedWork W2887481274 @default.
- W2071068913 hasRelatedWork W4254498133 @default.
- W2071068913 hasVolume "9" @default.
- W2071068913 isParatext "false" @default.
- W2071068913 isRetracted "false" @default.
- W2071068913 magId "2071068913" @default.
- W2071068913 workType "article" @default.