Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071072486> ?p ?o ?g. }
- W2071072486 endingPage "1158" @default.
- W2071072486 startingPage "1149" @default.
- W2071072486 abstract "BLM, the protein product of the gene mutated in Bloom syndrome, is one of five human RecQ helicases. It functions to separate double Holliday junction DNA without genetic exchange as a component of the dissolvasome, which also includes topoisomerase IIIα and the RMI (RecQ-mediated genome instability) subcomplex (RMI1 and RMI2). We describe the crystal structure of the RMI core complex, comprising RMI2 and the C-terminal OB domain of RMI1. The overall RMI core structure strongly resembles two-thirds of the trimerization core of the eukaryotic single-stranded DNA-binding protein, Replication Protein A. Immunoprecipitation experiments with RMI2 variants confirm key interactions that stabilize the RMI core interface. Disruption of this interface leads to a dramatic increase in cellular sister chromatid exchange events similar to that seen in BLM-deficient cells. The RMI core interface is therefore crucial for BLM dissolvasome assembly and may have additional cellular roles as a docking hub for other proteins." @default.
- W2071072486 created "2016-06-24" @default.
- W2071072486 creator A5006226657 @default.
- W2071072486 creator A5039794378 @default.
- W2071072486 creator A5042495366 @default.
- W2071072486 creator A5060740321 @default.
- W2071072486 creator A5075210236 @default.
- W2071072486 creator A5063943578 @default.
- W2071072486 date "2010-09-01" @default.
- W2071072486 modified "2023-09-27" @default.
- W2071072486 title "Structure and Cellular Roles of the RMI Core Complex from the Bloom Syndrome Dissolvasome" @default.
- W2071072486 cites W10876090 @default.
- W2071072486 cites W1520730837 @default.
- W2071072486 cites W1539796472 @default.
- W2071072486 cites W1965580483 @default.
- W2071072486 cites W1966950471 @default.
- W2071072486 cites W1970069044 @default.
- W2071072486 cites W1972932327 @default.
- W2071072486 cites W1973544851 @default.
- W2071072486 cites W1973871692 @default.
- W2071072486 cites W1974481952 @default.
- W2071072486 cites W1999757141 @default.
- W2071072486 cites W2020143772 @default.
- W2071072486 cites W2022390579 @default.
- W2071072486 cites W2025180999 @default.
- W2071072486 cites W2027814620 @default.
- W2071072486 cites W2035503835 @default.
- W2071072486 cites W2035692319 @default.
- W2071072486 cites W2039674107 @default.
- W2071072486 cites W2042056279 @default.
- W2071072486 cites W2042446618 @default.
- W2071072486 cites W2043545239 @default.
- W2071072486 cites W2056445557 @default.
- W2071072486 cites W2070781513 @default.
- W2071072486 cites W2076154132 @default.
- W2071072486 cites W2076744932 @default.
- W2071072486 cites W2080716570 @default.
- W2071072486 cites W2080992989 @default.
- W2071072486 cites W2082447947 @default.
- W2071072486 cites W2087746152 @default.
- W2071072486 cites W2102561949 @default.
- W2071072486 cites W2105901498 @default.
- W2071072486 cites W2112200653 @default.
- W2071072486 cites W2132587601 @default.
- W2071072486 cites W2132641227 @default.
- W2071072486 cites W2137955461 @default.
- W2071072486 cites W2144081223 @default.
- W2071072486 cites W2149045141 @default.
- W2071072486 cites W2162378349 @default.
- W2071072486 cites W2163341755 @default.
- W2071072486 cites W2167247319 @default.
- W2071072486 cites W89719521 @default.
- W2071072486 doi "https://doi.org/10.1016/j.str.2010.06.009" @default.
- W2071072486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2937010" @default.
- W2071072486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20826341" @default.
- W2071072486 hasPublicationYear "2010" @default.
- W2071072486 type Work @default.
- W2071072486 sameAs 2071072486 @default.
- W2071072486 citedByCount "33" @default.
- W2071072486 countsByYear W20710724862012 @default.
- W2071072486 countsByYear W20710724862013 @default.
- W2071072486 countsByYear W20710724862014 @default.
- W2071072486 countsByYear W20710724862015 @default.
- W2071072486 countsByYear W20710724862016 @default.
- W2071072486 countsByYear W20710724862017 @default.
- W2071072486 countsByYear W20710724862020 @default.
- W2071072486 countsByYear W20710724862021 @default.
- W2071072486 countsByYear W20710724862023 @default.
- W2071072486 crossrefType "journal-article" @default.
- W2071072486 hasAuthorship W2071072486A5006226657 @default.
- W2071072486 hasAuthorship W2071072486A5039794378 @default.
- W2071072486 hasAuthorship W2071072486A5042495366 @default.
- W2071072486 hasAuthorship W2071072486A5060740321 @default.
- W2071072486 hasAuthorship W2071072486A5063943578 @default.
- W2071072486 hasAuthorship W2071072486A5075210236 @default.
- W2071072486 hasBestOaLocation W20710724861 @default.
- W2071072486 hasConcept C102744134 @default.
- W2071072486 hasConcept C104317684 @default.
- W2071072486 hasConcept C130965112 @default.
- W2071072486 hasConcept C143425029 @default.
- W2071072486 hasConcept C161223559 @default.
- W2071072486 hasConcept C178169997 @default.
- W2071072486 hasConcept C2777576037 @default.
- W2071072486 hasConcept C2777867350 @default.
- W2071072486 hasConcept C2779013463 @default.
- W2071072486 hasConcept C2779071816 @default.
- W2071072486 hasConcept C30481170 @default.
- W2071072486 hasConcept C54355233 @default.
- W2071072486 hasConcept C552990157 @default.
- W2071072486 hasConcept C67705224 @default.
- W2071072486 hasConcept C70721500 @default.
- W2071072486 hasConcept C73573662 @default.
- W2071072486 hasConcept C8502773 @default.
- W2071072486 hasConcept C86803240 @default.
- W2071072486 hasConcept C95444343 @default.
- W2071072486 hasConceptScore W2071072486C102744134 @default.
- W2071072486 hasConceptScore W2071072486C104317684 @default.
- W2071072486 hasConceptScore W2071072486C130965112 @default.