FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071083535> ?p ?o ?g. }

• W2071083535 endingPage "326" @default.
• W2071083535 startingPage "317" @default.
• W2071083535 abstract "Background General anesthetics may modify airway responsiveness. The authors investigated the effect of thiopental, propofol, and etomidate on airway smooth muscle. Methods Contraction experiments were done in human airway rings that were either normal or passively sensitized with asthmatic serum. The effect of propofol and etomidate was also studied on both [Ca2+]i increase measured by microspectrofluorimetry in isolated myocytes and isometric contraction in the rat trachea. Results In human bronchi, thiopental (10[-7] to 10[-4] M) induced a concentration-dependent contraction. Neither propofol nor etomidate altered baseline tone, but both anesthetics reduced histamine-induced contraction. In human immunologically sensitized isolated bronchi, propofol (3 x 10[-4] M) reduced histamine reactivity (deltaFmax in %) to a greater degree than in nonsensitized tissues (64.4 +/- 15.7% and 16.4 +/- 8.5%, respectively; n = 6, P &lt; 0.05), whereas the effect of etomidate (10[-4] M) was similar in both types of tissue (24.1 +/- 6% and 22.3 +/- 15%, respectively, n = 6). In rat isolated tracheal myocytes, propofol (3 x 10[-4] M) and etomidate (10[-4] M) altered the [Ca2+]i signal in response to the depolarizing agent potassium chloride and the muscarinic agonist acetylcholine. Accordingly, the two anesthetics also reduced the mechanical response of rat tracheal rings to these agonists. Conclusions Whereas thiopental contracts human isolated bronchi, propofol and etomidate reduce histamine-induced contraction in human isolated airway smooth muscle that were either not sensitized or passively sensitized with asthmatic serum. This effect involves inhibition of both electro- and pharmacomechanical coupling." @default.
• W2071083535 created "2016-06-24" @default.
• W2071083535 creator A5011020394 @default.
• W2071083535 creator A5022964590 @default.
• W2071083535 creator A5044405886 @default.
• W2071083535 creator A5066385556 @default.
• W2071083535 creator A5066557148 @default.
• W2071083535 creator A5091822073 @default.
• W2071083535 date "1998-02-01" @default.
• W2071083535 modified "2023-10-03" @default.
• W2071083535 title "<b> <i>Effects of Intravenous Anesthetics on Normal and Passively Sensitized Human Isolated Airway Smooth Muscle</i> </b>" @default.
• W2071083535 cites W1931325223 @default.
• W2071083535 cites W1968160338 @default.
• W2071083535 cites W1985916155 @default.
• W2071083535 cites W2000410064 @default.
• W2071083535 cites W2004192706 @default.
• W2071083535 cites W2009769456 @default.
• W2071083535 cites W2018504160 @default.
• W2071083535 cites W2020707708 @default.
• W2071083535 cites W2030513399 @default.
• W2071083535 cites W2030681831 @default.
• W2071083535 cites W2030970425 @default.
• W2071083535 cites W2031689875 @default.
• W2071083535 cites W2032247326 @default.
• W2071083535 cites W2034155248 @default.
• W2071083535 cites W2038430146 @default.
• W2071083535 cites W2045166690 @default.
• W2071083535 cites W2057669458 @default.
• W2071083535 cites W2058197006 @default.
• W2071083535 cites W2063548614 @default.
• W2071083535 cites W2066127696 @default.
• W2071083535 cites W2068388424 @default.
• W2071083535 cites W2070178991 @default.
• W2071083535 cites W2070579159 @default.
• W2071083535 cites W2079664773 @default.
• W2071083535 cites W2082848204 @default.
• W2071083535 cites W2082962742 @default.
• W2071083535 cites W2085996153 @default.
• W2071083535 cites W2086591807 @default.
• W2071083535 cites W2089684592 @default.
• W2071083535 cites W2094902512 @default.
• W2071083535 cites W2111481535 @default.
• W2071083535 cites W2123885862 @default.
• W2071083535 cites W2131194885 @default.
• W2071083535 cites W2141260882 @default.
• W2071083535 cites W2149456573 @default.
• W2071083535 cites W2149493931 @default.
• W2071083535 cites W2156448363 @default.
• W2071083535 cites W2157984810 @default.
• W2071083535 cites W2168077736 @default.
• W2071083535 cites W2197937086 @default.
• W2071083535 cites W2229505874 @default.
• W2071083535 cites W2273849848 @default.
• W2071083535 cites W2397190434 @default.
• W2071083535 cites W2419395097 @default.
• W2071083535 cites W2436771044 @default.
• W2071083535 cites W78822087 @default.
• W2071083535 doi "https://doi.org/10.1097/00000542-199802000-00008" @default.
• W2071083535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9477050" @default.
• W2071083535 hasPublicationYear "1998" @default.
• W2071083535 type Work @default.
• W2071083535 sameAs 2071083535 @default.
• W2071083535 citedByCount "51" @default.
• W2071083535 countsByYear W20710835352013 @default.
• W2071083535 countsByYear W20710835352014 @default.
• W2071083535 countsByYear W20710835352015 @default.
• W2071083535 countsByYear W20710835352016 @default.
• W2071083535 countsByYear W20710835352017 @default.
• W2071083535 countsByYear W20710835352021 @default.
• W2071083535 countsByYear W20710835352022 @default.
• W2071083535 crossrefType "journal-article" @default.
• W2071083535 hasAuthorship W2071083535A5011020394 @default.
• W2071083535 hasAuthorship W2071083535A5022964590 @default.
• W2071083535 hasAuthorship W2071083535A5044405886 @default.
• W2071083535 hasAuthorship W2071083535A5066385556 @default.
• W2071083535 hasAuthorship W2071083535A5066557148 @default.
• W2071083535 hasAuthorship W2071083535A5091822073 @default.
• W2071083535 hasConcept C103486182 @default.
• W2071083535 hasConcept C1122143 @default.
• W2071083535 hasConcept C126322002 @default.
• W2071083535 hasConcept C163415756 @default.
• W2071083535 hasConcept C2775910092 @default.
• W2071083535 hasConcept C2776277131 @default.
• W2071083535 hasConcept C2779676917 @default.
• W2071083535 hasConcept C4141045 @default.
• W2071083535 hasConcept C42219234 @default.
• W2071083535 hasConcept C71924100 @default.
• W2071083535 hasConcept C98274493 @default.
• W2071083535 hasConceptScore W2071083535C103486182 @default.
• W2071083535 hasConceptScore W2071083535C1122143 @default.
• W2071083535 hasConceptScore W2071083535C126322002 @default.
• W2071083535 hasConceptScore W2071083535C163415756 @default.
• W2071083535 hasConceptScore W2071083535C2775910092 @default.
• W2071083535 hasConceptScore W2071083535C2776277131 @default.
• W2071083535 hasConceptScore W2071083535C2779676917 @default.
• W2071083535 hasConceptScore W2071083535C4141045 @default.
• W2071083535 hasConceptScore W2071083535C42219234 @default.
• W2071083535 hasConceptScore W2071083535C71924100 @default.

• next